Comparison of the effect of cefepime with four cephalosporins against pneumococci with various susceptibilities to penicillin, in vitro and in the mouse peritonitis model

The Journal of Antimicrobial Chemotherapy
J D KnudsenF Espersen

Abstract

The purpose of this study was to compare the effect, both in vitro and in vivo, of cefepime with those of four other cephalosporins, namely ceftriaxone, cefotaxime, cefuroxime and cephalothin, against penicillin-resistant pneumococci. One hundred pneumococcal strains, 31 penicillin-susceptible, 30 penicillin-intermediate-resistant and 39 penicillin-resistant pneumococci, were used in MIC studies. Time-kill experiments were carried out for four strains. In the mouse peritonitis model, the dose that gave protection to 50% of mice challenged with a lethal dose of pneumococci (ED50) was determined for three pneumococci and five cephalosporins. The MICs of all five cephalosporins and penicillin correlated significantly with each other. In vitro, the most potent cephalosporins against pneumococci were cefotaxime, ceftriaxone and cefepime, followed by cefuroxime and cephalothin. In time-kill experiments, carried out for four pneumococci, no differences were found in the killing effect of these five cephalosporins in relation to MICs. In the mouse peritonitis model, there was no significant correlation between log(MIC) and log(ED50) for the five cephalosporins against three pneumococci (Spearman's rho = 0.39, P = 0.16). However, if the...Continue Reading

Citations

Nov 4, 2009·Antimicrobial Agents and Chemotherapy·Jeffrey FernandezKaren Bush
Jul 21, 2009·Journal of Veterinary Pharmacology and Therapeutics·A GoudahA M Abd El-Aty
Sep 7, 2007·Journal of Veterinary Pharmacology and Therapeutics·B Joshi, S K Sharma
Aug 6, 2014·Antimicrobial Agents and Chemotherapy·Frederik Boetius HertzNiels Frimodt-Møller
Apr 29, 2006·Journal of Veterinary Science·Suresh Kumar Sharma, Anil Kumar Srivastava
Mar 25, 2015·Critical Care Medicine·Nicolas DufourJean-Damien Ricard
Nov 7, 2019·Tropical Animal Health and Production·Abdullah AltaybanMohammed Al-Nazawi
Apr 23, 2020·Antibiotics·Frederik Boetius HertzNiels Frimodt-Møller

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