Comparison of the effect of daily versus bolus dose maternal vitamin D3 supplementation on the 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 ratio

Bone
Hemamalini KethaRajiv Kumar

Abstract

Supplementing lactating mothers with high doses of vitamin D3 can adequately meet vitamin D requirements of the breastfed infant. We compared the effect of bolus versus daily vitamin D3 dosing in lactating mothers on vitamin D3 catabolism. We hypothesized that catabolism of 25(OH)D3 to 24,25(OH)2D3 would be greater in the bolus than in the daily dose group. Randomized controlled trial (clinicaltrials.govNCT01240265) in 40 lactating women. Subjects were randomized to receive vitamin D3 orally, either a single dose of 150,000IU or 5000IU daily for 28days. Vitamin D metabolites were measured in serum and breast milk at baseline, 1, 3, 7, 14 and 28days. Temporal changes in the serum 24,25(OH)2D3/25(OH)D3 ratio. The concentration of serum 24,25(OH)2D3 was directly related to that of 25(OH)D in both groups (r2=0.63; p<0.001). The mean (±SD) 24,25(OH)2D3/25(OH)D3 ratio remained lower at all time points than baseline values in the daily dose group (0.093±0.024, 0.084±0.025, 0.083±0.024, 0.080±0.020, 0.081±0.023, 0.083±0.018 at baseline, 1, 3, 7, 14, and 28days, respectively). In the single dose group, the increase in 24,25(OH)2D3 lagged behind that of 25(OH)D, but the 24,25(OH)2D3/25(OH)D3 values (0.098±0.032, 0.067±0.019, 0.081±0.017,...Continue Reading

Associated Clinical Trials

References

Jun 1, 1989·Pediatric Research·T HoogenboezemH K Visser
Jan 1, 1983·Annual Review of Biochemistry·H F DeLuca, H K Schnoes
Apr 1, 1984·Physiological Reviews·R Kumar
Jul 1, 1981·The Journal of Nutrition·B W HollisP W Lambert
Jul 1, 1982·The American Journal of Clinical Nutrition·L E ReeveH F DeLuca
May 15, 1980·The New England Journal of Medicine·R KumarF H Epstein
Dec 9, 2004·The American Journal of Clinical Nutrition·Hector F DeLuca
Jul 31, 2007·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Carol L WagnerBruce W Hollis
Jun 17, 2011·The New England Journal of Medicine·Karl P SchlingmannMartin Konrad
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zachary C RyanRajiv Kumar
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Thomas P JacobsJohn P Bilezikian
Nov 21, 2015·Clinical Chemistry·Hemamalini KethaRavinder J Singh
May 1, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D T O'KeeffeR A Wermers
Apr 5, 2017·Annals of Family Medicine·Puja J UmaretiyaTom D Thacher

❮ Previous
Next ❯

Citations

Oct 6, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Neil C Binkley, Donald A Wiebe
Dec 6, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Markus Herrmann
Jun 6, 2020·Food & Function·Ida Emilie I LindahlHanne Christine Bertram
Mar 30, 2020·Hormones : International Journal of Endocrinology and Metabolism·Konstantinos MakrisEtienne Cavalier
Jul 17, 2020·Frontiers in Public Health·Mardi A Crane-GodreauSteven Fiering
Sep 26, 2019·Advances in Nutrition·Karen M O'CallaghanDaniel E Roth
Dec 12, 2020·The Cochrane Database of Systematic Reviews·May Loong TanDavid A Osborn
May 20, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Pauline M CamachoNelson B Watts
Jan 6, 2021·International Breastfeeding Journal·Mojtaba KeikhaRoya Kelishadi
Jan 26, 2021·Royal Society Open Science·George GriffinDavid Thickett
Dec 29, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Arpana IyengarRukshana Shroff
Mar 14, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Konstantinos MakrisAnnemieke C Heijboer
Jun 25, 2021·Journal of Endocrinological Investigation·R PalA Vyas
Sep 2, 2021·Animal Nutrition·Lianhua Zhang, Xiangshu Piao
Aug 10, 2021·Nutrition Research Reviews·Inez SchoenmakersAlastair Forbes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.