Comparison of the effect of dietary copper nanoparticles and one copper (II) salt on the metabolic and immune status in a rat model

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Ewelina CholewińskaKatarzyna Ognik

Abstract

The aim of the study was to evaluate the effects of a diet containing different levels of Cu in two different chemical forms (carbonate and nanoparticles) on metabolic, immune and antioxidant status in a rat model. Five experimental treatments (8 rats in each) were used to test different dosages of Cu added to the diet (standard -6.5 mg/kg, half the standard dosage -3.25 mg/kg, and no added Cu as a negative control) and two sources of added copper (standard -CuCO3 and copper nanoparticles -CuNPs). Blood and urine samples were collected from all the animals after four weeks of treatment. Metabolic and immune parameters were determined in blood and urine samples. The study has shown that a dietary Cu deficiency (negative control) decreases rat's plasma levels of Cu, Fe, CREAT, BIL and IL-6, whereas reducing the level of Cu from the recommended 6.5 mg/kg to 3.25 mg/kg decreases only the plasma concentration of TG, IgE and IL-6. Replacing CuCO3 with CuNPs in rat diets affects their metabolism, as indicated by decreased Ca, CREAT, BIL, ALB and IL-6 plasma levels. To sum up, CuNP added to a diet of rats have a more beneficial effect on metabolic indices (indicative of kidney and liver function) and inhibit inflammatory processes more...Continue Reading

Citations

Jan 9, 2019·Journal of Animal Physiology and Animal Nutrition·Katarzyna OgnikRadosław Szlązak
Dec 27, 2019·Archives of Environmental & Occupational Health·Souhir OuniSalem Amara
Sep 21, 2019·Journal of Animal Physiology and Animal Nutrition·Katarzyna OgnikJerzy Juśkiewicz
May 14, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Monika Cendrowska-PinkoszKatarzyna Ognik
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Azza A AttiaNahla S El-Shenawy

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