Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats

International Journal of Molecular Sciences
Lisa RancanJesús A F Tresguerres

Abstract

Aging is associated with an increase in stroke risk. Melatonin, a potent free radical scavenger and broad spectrum antioxidant, has been shown to counteract inflammation and apoptosis in brain injury. However, little is known on the possible protective effects of melatonin in aged individuals affected by brain ischemia. Also, using melatonin before or after an ischemic stroke may result in significantly different molecular outcomes. The objective of the present study was to compare the effects of pre-ischemia vs. post-ischemia melatonin administration in an ischemic lesion in the cortex and hippocampus of senescent Wistar rats. An obstruction of the middle cerebral artery (MCA) to 18-month-old animals was performed. In general, animals treated with melatonin from 24 h prior to surgery until 7 days after the surgical procedure (PrevT) experienced a significant decrease in the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), glial fibrillary acidic protein (GFAP), Bcl-2-associated death promoter (BAD), and Bcl-2-associated X protein (BAX) in both cortex and hippocampus, while hippocampal levels of sirtuin 1 (SIRT1) and B-cell lymphoma 2 (Bcl-2) increased. Treatment of animals with melatonin only after surgery (A...Continue Reading

References

Nov 1, 1981·Stroke; a Journal of Cerebral Circulation·J AstrupL Symon
Jun 1, 1981·Journal of Neurosurgery·T H JonesR G Ojemann
Oct 1, 1994·Annals of Neurology·K A Hossmann
Aug 7, 1998·Journal of Pineal Research·C MésengeM Plotkine
Sep 3, 1998·Neuroscience Letters·P A SperaF C Barone
Aug 11, 1999·Trends in Neurosciences·U DirnaglM A Moskowitz
Sep 9, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C FerrareseM G De Simoni
Mar 18, 2000·Advances in Experimental Medicine and Biology·R J ReiterD D'Arpa
May 3, 2003·Nature Reviews. Neuroscience·Eng H LoMichael A Moskowitz
Jan 31, 2006·Journal of Pineal Research·Andrew W SiuRussel J Reiter
Oct 4, 2006·Journal of Pineal Research·Jochen H WeishauptHannelore Ehrenreich
Mar 17, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Javier R CasoJuan C Leza
May 15, 2007·Current Opinion in Neurology·Keith W MuirElizabeth Warburton
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
May 13, 2008·Lancet·Geoffrey A DonnanStephen M Davis
Aug 19, 2008·Journal of Pineal Research·Javier Gutierrez-CuestaMercè Pallàs
Nov 13, 2014·Hormone Molecular Biology and Clinical Investigation·Sergio D ParedesJesús A F Tresguerres
Dec 11, 2014·Journal of Neurochemistry·Danielle N DollJames W Simpkins
Jan 10, 2017·Free Radical Biology & Medicine·Eva RamosJavier Egea
Jan 22, 2017·Journal of Pineal Research·Juan C MayoRussel J Reiter

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Citations

Jan 28, 2020·The European Journal of Neuroscience·Natália Pipová KokošováBeňadik Šmajda
Aug 1, 2020·Antioxidants·Nadia SadanandanCesar V Borlongan
Nov 30, 2019·International Journal of Molecular Sciences·Mónica De la Fuente
Nov 3, 2020·BioFactors·Nuttapong YawootJiraporn Tocharus

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