Comparison of the effect of toothpastes containing enzymes or antimicrobial compounds with a conventional fluoride toothpaste on the development of plaque and gingivitis

Journal of Clinical Periodontology
J MoranR G Newcombe

Abstract

Many toothpastes have been formulated over recent years to contain antimicrobial compounds with the aim of preventing or reducing plaque, calculus, gingival inflammation or dental caries. For many, if not all of these toothpastes, it has yet to be proven whether they are significantly better at reducing plaque and gingivitis than conventional toothpastes, for which no such therapeutic effects have been claimed. This 12-day, incomplete block designed, cross-over study compared the development of plaque and gingivitis following rinsing with toothpaste slurries containing the following active ingredients: (1) hexetidine/zinc citrate, (2) 0.2% triclosan, (3) amyloglucosidase/glucose oxidase, (4) sodium fluoride/sodium monofluorophosphate (NaF, MFP). By the 8th day of the study, a significant difference in gingival crevicular fluid (GCF) and GI was found between the groups. By day 12, however, no significant difference in plaque index and gingival inflammation was found between the 4 toothpastes, although plaque area was significantly reduced with the hexetidine/zinc citrate paste when compared to the conventional fluoride paste. It was concluded that the active ingredients added to the toothpastes evaluated in this study provided l...Continue Reading

References

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Citations

Feb 1, 1991·Journal of Clinical Periodontology·S JenkinsR Newcombe
Sep 1, 1992·Journal of Clinical Periodontology·J MoranS Roberts
Jan 1, 1993·Journal of Clinical Periodontology·S JenkinsR Newcombe
Dec 14, 2011·Clinical Oral Investigations·Marieke P T OttenChris G van Hoogmoed
Mar 18, 2011·European Journal of Oral Sciences·Marieke P T OttenFrank Abbas
Feb 8, 2005·European Journal of Oral Sciences·Christian HannigThomas Attin
Feb 1, 1991·Journal of Clinical Periodontology·S JenkinsR Newcome
Jun 28, 2019·International Journal of Environmental Research and Public Health·Hsin-Chung ChengYa-Chu Chang
Oct 9, 2020·International Journal of Dental Hygiene·Ashwin Parakkaje SubramanyaPrabhuji Mlv
Jan 18, 2021·Colloids and Surfaces. B, Biointerfaces·Sam R AspinallVitaliy V Khutoryanskiy
Dec 1, 1994·Journal of Dentistry·P A Heasman, R A Seymour

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