PMID: 9179542May 1, 1997Paper

Comparison of the effect of two low-density lipoprotein receptor class mutations on coronary heart disease among French-Canadian patients heterozygous for familial hypercholesterolaemia

European Journal of Clinical Investigation
M C VohlJ P Després

Abstract

The aim of this study was to compare the age at first elective coronary angiogram and the age at first revascularization (coronary artery bypass grafting or percutaneous transluminal coronary angioplasty) in 102 patients without familial hypercholesterolaemia (FH), who were matched for age and sex with 76 heterozygous FH patients carrying a defective allele at the low-density lipoprotein (LDL) receptor gene (LDL-R) and 26 heterozygous FH patients bearing a null mutation at the LDL-R. The prevalence of diabetes was significantly higher in the non-FH group than in the two FH groups (P < 0.05). Furthermore, mean body mass index (BMI) and waist circumference values were also higher in the non-FH group than in the two FH heterozygous groups (P < 0.005). However, FH patients who were null allele carriers had the highest plasma total and LDL-cholesterol levels and the highest cholesterol/HDL-cholesterol ratio, whereas the defective allele carriers group had intermediate levels between null allele carriers and non-FH patients. Comparison of the age at first coronary angiography revealed that the null allele carriers group were younger at first angiogram than the non-FH patients (P < 0.005). In addition, a trend was observed for a young...Continue Reading

Citations

Jul 4, 2012·Indian Journal of Clinical Biochemistry : IJCB·E FarrokhiM Hashemzadeh Chaleshtori
Jan 20, 1999·European Journal of Clinical Investigation·X Pintó
Dec 12, 2001·European Journal of Clinical Investigation·O S DescampsF R Heller
Apr 29, 1998·Current Opinion in Lipidology·A K Soutar
Sep 18, 1998·Current Opinion in Lipidology·P NichollsC A Graham
Nov 26, 2010·Current Opinion in Lipidology·Arnold von Eckardstein, Rahel A Sibler
Nov 8, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Athanasios VergopoulosHerbert Schuster
Dec 19, 2015·Expert Review of Cardiovascular Therapy·Joost Besseling, Barbara A Hutten
Jun 18, 2004·European Journal of Clinical Investigation·G V Z DedoussisC Stefanadis
Jan 24, 2017·Drug Discovery Today·Amir Abbas MomtaziAmirhossein Sahebkar
Apr 12, 2001·European Journal of Clinical Investigation·F J ChavesM E Armengod
Oct 30, 2015·Circulation·Samuel S GiddingUNKNOWN American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascula
Nov 14, 2015·Diabetes & Metabolism Journal·Klaus G Parhofer
Feb 6, 2020·Clinical and Experimental Pharmacology & Physiology·Myung Han HyunHong Seog Seo
Jul 1, 2017·Frontiers in Pharmacology·Qi YuCang-Bao Xu
Nov 4, 2004·Human Mutation·George V Z DedoussisJanine Genschel
Mar 25, 2020·Trends in Cardiovascular Medicine·Vanessa BianconiUNKNOWN International Lipid Expert Panel (ILEP)
Apr 24, 2021·Internal Medicine Journal·Antonina GiammancoMaurizio R Averna

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