PMID: 11604265Oct 18, 2001Paper

Comparison of the effect of ultrasound and of chemical enhancers on transdermal permeation of caffeine and morphine through hairless mouse skin in vitro

International Journal of Pharmaceutics
D MontiS Burgalassi

Abstract

The effect of ultrasound (US) on permeation of two model drugs, caffeine (CAF) and morphine (MOR), through hairless mouse skin in vitro was compared with that of three chemical enhancers. Low-frequency (40 KHz), low-power (<0.5 W/cm(2)) US was used; the effect of high-frequency US (1.5-3.0 MHz) was also evaluated in the case of CAF. The chemical enhancers, tested in combination with propylene glycol (PG), were benzalkonium chloride (BAC) oleyl alcohol (OA) and alpha-terpineol (TER). The high-frequency US enhancement of CAF transdermal flux was not statistically significant, while low frequency produced a small but significant increase of the enhancement factor. The effect of US on CAF permeation, however, was lower than that produced by chemical enhancers, in particular OA. The effect of low-frequency US on permeation of MOR was significantly greater (about 10-fold) when compared, on the same frequency and intensity basis, with the effect on CAF. The most active chemical enhancer for MOR, OA, had practically the same effect as low-frequency US. Sonicated skin, although showing slight histological changes, recovered its original low permeability characteristics after turning off sonication. Within the tested system, chemical enh...Continue Reading

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Citations

Aug 1, 2013·Ultrasonics·Donghee ParkSeunghun Lee
Sep 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amit Joshi, Jaideep Raje
Aug 15, 2002·International Journal of Pharmaceutics·L Machet, A Boucaud
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Jan 2, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ilana LavonGiora Enden
Jun 10, 2009·The Journal of Pharmacy and Pharmacology·Rekha Rao, Sanju Nanda
Jul 29, 2004·Drug Discovery Today·Ilana Lavon, Joseph Kost
Mar 6, 2004·Pharmaceutical Development and Technology·Dimitrios A DimasDimitrios M Rekkas
Apr 7, 2016·Pharmaceutical Development and Technology·R M BarbosaM H A Santana
Sep 22, 2007·The Journal of Pharmacy and Pharmacology·Kevin B ItaJeanetta du Plessis
Jul 10, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Franklin K AkomeahMarc B Brown
Sep 17, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ilana LavonJoseph Kost

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