Comparison of the effectiveness between a single low dose and fractionated doses of radioiodine in ablation of post-operative thyroid remnants

Japanese Journal of Clinical Oncology
Guang-Uei HungKwang-Tao Yang

Abstract

Due to the lack of radiation isolation wards in most hospitals in Taiwan, high-dose (exceeding 30 mCi) radioiodine therapy is usually performed in a fractionated manner (successively administering multiple low doses). This study compared the ablating efficacies of post-operative thyroid remnants using a single low dose (30 mCi) and fractionated doses (four doses of 30 mCi given at weekly intervals) in 59 patients with differentiated thyroid cancer who received total or near-total thyroidectomy. Successful ablation was obtained in 20 of 38 patients (52.6%) treated with a single low dose compared with 14 of 21 patients (66.7%) treated in a fractionated manner. There was no statistically significant difference between these two treatment protocols (P = 0.296). As the fractionated-dose protocol has the drawbacks of a much longer hypothyroid state and a higher total expense, we suggest that a single low dose is more feasible than fractionated doses for outpatient ablation therapy.

Citations

Dec 17, 2005·Thyroid : Official Journal of the American Thyroid Association·Rafał CzepczyńskiJerzy Sowiński
Oct 13, 2006·The Journal of Clinical Endocrinology and Metabolism·Allan HackshawJayne A Franklyn
Oct 29, 2019·The Journal of Clinical Pediatric Dentistry·Eman Abu-ObaidSayed Auda

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