Comparison of the effectiveness of passive (dam) versus active (piglet) immunization against porcine circovirus type 2 (PCV2) and impact of passively derived PCV2 vaccine-induced immunity on vaccination

Veterinary Microbiology
Tanja OpriessnigPatrick G Halbur

Abstract

The objectives of this study were (1) to compare the efficacy of two different PCV2 vaccination protocols (colostrum-derived immunity versus piglet vaccination) in a conventional PCV2 growing pig challenge model and (2) to evaluate the efficacy of vaccinating piglets with the same vaccine used in the dams. Two different commercially available vaccines (VAC1; VAC2) were used in the same experiment. Seventy-eight piglets born to vaccinated or non-vaccinated sows were divided into 8 groups. A proportion of the pigs with and a proportion of the pigs without passively acquired immunity were vaccinated at 21 days of age. All pigs except negative controls were challenged with PCV2b at 35 days post-vaccination and necropsied at 21 days post-challenge (dpc). The data indicates that both dam vaccination and piglet vaccination had similar efficacies in reducing PCV2 viral loads and antigen levels in the growing pigs. Interestingly, dam vaccination alone did result in significantly (P<0.05) lower anti-PCV2-antibodies levels at challenge in piglets from dams immunized with VAC2 compared to piglets from VAC1 immunized dams. When data obtained from the growing piglets that were vaccinated with VAC1 or VAC2 were compared, antibody levels and r...Continue Reading

References

Feb 26, 2000·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·G M Allan, J A Ellis
Sep 13, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·S D SordenP S Paul
Nov 9, 2005·Clinical and Diagnostic Laboratory Immunology·N E McKeownX J Meng
Nov 14, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Tanja OpriessnigPatrick G Halbur
Mar 18, 2008·Journal of the American Veterinary Medical Association·Kyle P HorlenRaymond R R Rowland
Nov 7, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Darin M MadsonTanja Opriessnig

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Citations

Mar 19, 2013·Virus Research·Cheryl M T DvorakMichael P Murtaugh
Feb 3, 2016·The Veterinary Record·E CanelliP Martelli
Sep 17, 2015·The Veterinary Record·P MartelliP Borghetti
Jan 19, 2012·Transboundary and Emerging Diseases·P BaekboL E Larsen
Jun 8, 2014·Veterinary Microbiology·Hua FengMarina Sibila
Jul 23, 2013·Veterinary Microbiology·Cheryl M T DvorakMichael P Murtaugh
Jun 5, 2016·Veterinary Microbiology·Cheryl M T DvorakMichael P Murtaugh
Jan 1, 2013·Annual Review of Animal Biosciences·Xiang-Jin Meng
Sep 24, 2011·Clinical and Vaccine Immunology : CVI·K C O'NeillT Opriessnig
Nov 18, 2014·Expert Review of Vaccines·Joaquim Segalés
Jun 18, 2015·Porcine Health Management·Charlotte S KristensenLars E Larsen
Sep 21, 2018·Frontiers in Microbiology·Yuhong PanAnchun Cheng
Apr 6, 2021·Journal of Veterinary Research·Carlos DíazIvo Frébort
Jul 21, 2021·Journal of Animal Science·Natália Galoro LeiteDaniela Lourenco

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