PMID: 2484920Dec 1, 1988Paper

Comparison of the effectiveness of dihydroquinidine and quinidine on ventricular ectopy after acute and chronic administration

Cardiovascular Drugs and Therapy
M ChimientiC Montemartini

Abstract

The aim of this study was to compare the pharmacokinetics and antiarrhythmic activity of dihydroquinidine and quinidine in 14 patients (11 men, 3 women, aged 28 to 67 years) with heart disease and chronic, stable, high-frequency premature ventricular beats (PVB) (greater than 100/hr). A randomized, double-blind, crossover, placebo-controlled protocol was utilized. During Holter monitoring the patients were given either dihydroquinidine or quinidine as the gluconates in an oral solution (600 mg); blood samples were taken 0.5, 1, 1.5, 2, 4, 6, 8, and 12 hours later. The patients were then assigned to three successive treatment periods of 7 days each: dihydroquinidine HCl (900 mg/day), quinidine polygalacturonate (1,650 mg/day), or placebo. At the end of each period 24-hour Holter monitoring was carried out and a blood sample was taken for determination of drug concentration. By comparing the area under the curves dihydroquinidine was 59% as available as quinidine; rates of absorption and elimination were similar. Mean peak blood levels of dihydroquinidine and quinidine were 1.06 +/- 0.34 and 2.15 +/- 0.96 micrograms/ml, respectively. After dihydroquinidine, eight patients had a positive response (greater than 50% reduction in PVB...Continue Reading

References

Dec 1, 1979·American Heart Journal·N H CarlinerG D Plotnick
Nov 23, 1976·The American Journal of Cardiology·C E GaughanH W Besser
Jan 1, 1987·The American Journal of Cardiology·J MorganrothG Chao
Jan 1, 1981·European Journal of Clinical Pharmacology·D M HaileyW J Smith
Dec 1, 1980·Circulation·M SamiR F DeBusk

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