PMID: 15374317Nov 1, 1993Paper

Comparison of the effects of aging in vivo and of oxygen free radicals in vitro on high-affinity choline uptake and hemicholinium-3 binding in the rat brain

Archives of Gerontology and Geriatrics
Z KristofikováH Tejkalová

Abstract

The effects of aging in vivo (Wistar rats aged 3-26 months) and of an oxygen free-radical generating system in vitro (Fe(2+)/ascorbic acid) on high-affinity choline uptake in the hippocampus and on (3H)hemicholinium-3 binding sites in the cortex and hippocampus are compared. The high-affinity choline transport system was found to be more damaged than the low-affinity system during aging (Na(+)-dependent part of the uptake drops to 76%: Na(+)-independent part increases to 120%). The decrease in high-affinity choline uptake values is probably more influenced by the impairment of correct function of carriers (the fall in the turnover rate of each carrier) than by a decrease in the number of transport sites (no change of the density of the carriers in the hippocampus and cortex). The causes of the defect in high-affinity choline transport during aging are discussed.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jul 1, 1976·Journal of Neurochemistry·J R Simon, M J Kuhar
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M M Zaleska, M Erecińska
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Jul 1, 1983·Analytical Biochemistry·R F BrunsT A Pugsley
Jan 1, 1981·Neurobiology of Aging·K A ShermanE Friedman
Jul 1, 1956·Journal of Gerontology·D HARMAN
Jul 1, 1992·Archives of Gerontology and Geriatrics·Z KristofikováO Benecsová

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Citations

Sep 23, 2010·Biogerontology·Iva HolmerováBozena Jurasková
Dec 25, 2002·Neurobiology of Aging·S FavrelièreG Durand
Nov 18, 2011·Neurochemical Research·Zdena KrištofikováJaroslav Koča
Feb 24, 2005·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Pushpalatha KakarlaSathyavelu Reddy Kesireddy
Jun 26, 2018·Journal of Geophysical Research. Atmospheres : JGR·H MoonS I Seneviratne

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