Comparison of the effects of aqueous and gellan ophthalmic timolol on peak exercise performance in middle-aged men

American Journal of Ophthalmology
K Dickstein, T Aarsland

Abstract

To compare the effects of 0.5% aqueous timolol and 0.5% timolol gellan on exercise performance in middle-aged men. We evaluated the effects of 0.5% aqueous timolol (timolol solution, administered twice daily, and a 0.5% timolol gellan suspension that forms a gel on application to the conjunctiva (timolol gellan), administered once daily, on exercise performance in 42 healthy men with a mean age of 58 years (range, 55 to 65 years). Serum concentrations of timolol were assayed. Subjects exercised maximally on an upright cycle ergometer four times with ten-day intervals. After baseline testing, subjects were randomly assigned and crossed over in a double-masked manner to two and a half days of treatment with placebo, 0.5% timolol solution, and 0.5% timolol gellan. The serum timolol concentrations immediately after testing were 0.91 +/- 0.51 ng/ml for timolol solution compared to 0.71 +/- 0.46 ng/ml for timolol gellan (P < .05). The change from baseline in resting heart rate was -1.8 +/- 9.3 beats/min (P = .23) for placebo, -11.0 +/- 9.6 beats/min (P < .001) for timolol gellan. The change from baseline in peak heart rate was -0.1 +/- 7.3 beats/min (P = .92) for placebo, -15.6 +/- 5.6 beats/min (P < .001) for timolol solution, and -...Continue Reading

References

Nov 15, 1986·American Journal of Ophthalmology·W L NelsonJ N Kuritsky
Jan 1, 1985·Journal of Ocular Pharmacology·T KailaR Huupponen
Feb 1, 1986·Annals of Internal Medicine·C V LeierP A Weber
Feb 1, 1986·Circulation Research·M B HigginbothamF R Cobb
Feb 15, 1985·American Journal of Ophthalmology·J M AtkinsR M Timewell
Oct 1, 1984·Archives of Ophthalmology·W J DoyleR H Meeks
Jan 1, 1993·Journal of Ocular Pharmacology·T J Zimmerman
Oct 1, 1993·Journal of Glaucoma·J LaurenceT J Zimmerman

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Citations

Apr 16, 1998·Progress in Retinal and Eye Research·C L BourlaisR Leverge
Oct 17, 2006·Wiener medizinische Wochenschrift·Hemma Resch, Gerhard Garhofer
May 25, 2005·European Journal of Clinical Pharmacology·Tuomo NieminenMika Kähönen
Apr 22, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hannu UusitaloVäinö Turjanmaa
Jun 21, 2005·La Presse médicale·Marc LabetoulleClaire Le Jeunne
Jan 7, 2006·Acta Ophthalmologica Scandinavica·Hannu UusitaloMika Kähönen
Mar 24, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Abhishek K Sah, Preeti K Suresh
Sep 9, 2015·Case Reports in Critical Care·Muhammad Asim RanaWaleed Tharwat Aletreby
Nov 18, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Marjo VolotinenEsko Aine
Apr 16, 2015·Journal of Ophthalmology·Nicole L PrattElizabeth E Roughead
Jun 13, 2002·Acta Ophthalmologica Scandinavica·William C StewartAngi L Jackson
Oct 31, 2002·Clinical Physiology and Functional Imaging·J NiñoM Kähönen
Jun 29, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·W C StewartJ A Stewart
Mar 18, 2008·Journal of Glaucoma·Deepta Ghate, Henry F Edelhauser
Mar 16, 2001·Expert Opinion on Pharmacotherapy·A W Talbot, I Russell-Eggitt
Mar 19, 2019·Current Medical Research and Opinion·George RennieGiovanni Strippoli
Jun 14, 2019·Journal of Ophthalmology·Letizia NegriMichele Iester
Apr 25, 2015·European Journal of Ophthalmology·Ashraf A KhanPankaj Agarwal
Mar 17, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·T NieminenM Kähönen
Jul 19, 2018·Purinergic Signalling·Tali Fishman JacobBilha Fischer
Nov 26, 2020·American Journal of Clinical Dermatology·Daniel J YoonR Rivkah Isseroff
Aug 29, 1997·Journal of Medicinal Chemistry·M F Sugrue

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