Comparison of the effects of arabinosyladenine, arabinosylhypoxanthine, and arabinosyladenine 5'-monophosphate against herpes simplex virus, varicella-zoster virus, and cytomegalovirus with their effects on cellular deoxyribonucleic acid synthesis.

Antimicrobial Agents and Chemotherapy
J F Gephart, A M Lerner

Abstract

In a single line of human foreskin fibroblasts, minimum inhibitory concentrations (MICs) and the minimum intracellular virus inactivation concentrations (MIICs) of arabinosyladenine, arabinosylhypoxanthine, and arabinosyladenine 5'-monophosphate were assayed for a number of recent isolates of herpes simplex virus types 1 and 2 (HSV-1, HSV-2), varicella-zoster virus (VZV), and cytomegalovirus (CMV). (The term MIIC is used here to describe the selective qualitative intracellular inhibition of the virus inoculum in the primary tissue cultures. The inoculum is not recoverable in subcultures free of antiviral agent.) MICs and MIICs of each of the antiviral agents were readily obtained for each strain of HSV-1, HSV-2, and VZV tested, but all seven strains of CMV tested were much more resistant. At the endpoint, there was little variation in the MICs or MIICs among strans of the same virus. Final MIC results for HSV-1 and HSV-2 were complete after 3 days of incubation; CMV and VZV results required as long as 6 days. The MIC for each herpesvirus increased with incubation, but at the endpoint the MIC and MIIC were approximately equal. VZV was most susceptible to each drug, followed by HSV-1 and HSV-2. The latter two viruses were quite s...Continue Reading

References

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Citations

Sep 1, 1988·Antiviral Research·L R Stanberry, M G Myers
Oct 20, 1983·The New England Journal of Medicine·M S Hirsch, R T Schooley
Apr 1, 1984·Antimicrobial Agents and Chemotherapy·S R PrebludS A Plotkin
Jul 1, 1985·Antimicrobial Agents and Chemotherapy·E De Clercq
Oct 1, 1991·Antimicrobial Agents and Chemotherapy·K K BironT A Krenitsky
Jul 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A PonzettoE Chiaberge
Nov 13, 2004·Antiviral Chemistry & Chemotherapy·Kunikazu KurosakiKimiyasu Shiraki
Feb 1, 1982·Antimicrobial Agents and Chemotherapy·H MachidaH Yoshino

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