Comparison of the effects of auranofin and retinoic acid on plasminogen activator activity of peritoneal macrophages and Lewis lung carcinoma cells

Biochemical Pharmacology
D LisonR Lauwerys

Abstract

Urokinase-type plasminogen activator, a neutral proteinase, seems to play a central role in the degradation of the extracellular matrix that accompanies a number of biological phenomena including inflammatory reactions and neoplasia. The effect of auranofin and retinoic acid on the plasminogen activator activity expressed by two cell types, i.e. murine macrophages and Lewis lung carcinoma cells, has been investigated. Low concentrations of both drugs (10(-6)-10(-7) M) can inhibit in vitro the induction of plasminogen activator in macrophages stimulated by phorbol 12-myristate 13-acetate. This action occurs rapidly (15 min), is irreversible and is independent of a global cytotoxic effect. Auranofin and retinoic acid remain without effect in macrophages when added after stimulation by the phorbol ester. Both drugs are thus potent inhibitors of the induction of plasminogen activator activity in macrophages, possibly through an interaction with the protein kinase C system. The plasminogen activator activity of Lewis lung carcinoma cells, which is apparently not dependent on a protein kinase C pathway, is not influenced by auranofin or retinoic acid. These observations may contribute to explain: (1) the activity of auranofin and ret...Continue Reading

References

Jul 1, 1978·The Journal of Experimental Medicine·A Granelli-Piperno, E Reich
Dec 1, 1978·Immunochemistry·R J Mallie, J S Garvey
Nov 1, 1987·Thrombosis Research·J C KirchheimerB R Binder
Nov 25, 1987·Biochimica Et Biophysica Acta·K TryggvasonT Salo
Jan 1, 1985·Advances in Cancer Research·K DanøL Skriver
Jul 18, 1986·Science·Y Nishizuka
Mar 1, 1987·Biochemical Pharmacology·M FroscioN P Hurst
Oct 15, 1986·Biochemical Pharmacology·S T CrookeC K Mirabelli
Jun 15, 1987·Biochemical and Biophysical Research Communications·K SekiguchiY Nishizuka
Mar 1, 1987·Biochemical Pharmacology·R M SnyderS T Crooke
Aug 21, 1980·The New England Journal of Medicine·C E BrinckerhoffE D Harris
Dec 29, 1983·Biochimica Et Biophysica Acta·D E Mullins, S T Rohrlich
Jan 1, 1984·Annals of Internal Medicine·E D Harris
Aug 12, 1983·Biochemical and Biophysical Research Communications·S M TaffetM K Haddox

❮ Previous
Next ❯

Citations

Nov 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D LisonR Lauwerys
Mar 5, 2008·Journal of Thrombosis and Haemostasis : JTH·G MarchettiF Bernardi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.