Comparison of the effects of calcium and the calcium channel stimulant Bay k 8644 on neomycin-induced neuromuscular blockade.

Pharmacology & Toxicology
J M Baeyens, E Del Pozo

Abstract

The effects of calcium and the calcium channel stimulant Bay k 8644 on neomycin-induced neuromuscular blockade were evaluated using rat phrenic nerve-hemidiaphragm preparations in vitro. neomycin showed maximum potency in inducing neuromuscular blockade when the calcium concentration in the bath was 1 mM. Higher calcium concentrations (1.5, 2 and 4 mM) produced a gradual decrease in neomycin potency, manifested as a progressive shift to the right of neomycin concentration-response curves. Bay k 8644 (0.1 and 1 microM) did not significantly modify indirectly elicited diaphragm contractions per se, nor did it antagonize neomycin-induced neuromuscular blockade. A higher concentration of Bay k 8644 (10 microM) antagonized indirectly elicited contractions. In conclusion, our results show that Bay k 8644, at concentrations causing calcium channel stimulation at the cardiac and vascular level, did not exert stimulant effects in a nerve-skeletal muscle preparation, suggesting that its action may be tissue-selective to a certain degree.

References

Aug 1, 1975·British Journal of Pharmacology·H R Adams
Aug 15, 1985·European Journal of Pharmacology·G FranckowiakG Thomas
Dec 1, 1987·British Journal of Anaesthesia·F A Wali, A H Suer
Aug 22, 1986·European Journal of Pharmacology·E Del Pozo, J M Baeyens
Dec 1, 1985·British Journal of Pharmacology·H Lüllmann, B Schwarz
Jan 1, 1972·Annual Review of Pharmacology·C Pittinger, R Adamson
Feb 1, 1982·British Journal of Anaesthesia·F G Standaert
Sep 1, 1982·Pflügers Archiv : European journal of physiology·N HinoT Yanagisawa

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