Comparison of the effects of chlormadinone acetate versus drospirenone containing oral contraceptives on metabolic and hormonal parameters in women with PCOS for a period of two-year follow-up

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Recep YildizhanNuman Cim

Abstract

A randomized trial to compare the effects of two oral contraceptive pills containing either chlormadinone acetate or drospirenone as the progestogen, in women with PCOS for a period of two-year follow-up. Group A received ethinyl-estradiol 0.03 mg + drospirenone 3 mg (EE + DRSP; n = 56) and Group B received ethinyl-estradiol 0.03 mg + chlormadinone acetate 2 mg (EE + CMA; n = 50). Clinical, hormonal and biochemical parameters were compared at baseline, 6 months, 12 months and 24 months. The increase in total cholesterol and hsCRP levels was statistically significantly higher at 6, 12 and 24 months in Group B when compared with Group A. The change in the high-density lipoprotein cholesterol level at the 24 months of treatment was statistically significantly higher in Group A. Group A has a significantly higher reduction in FAI at 6 and 24 months, in FGS at 6, 12 and 24 months and in HOMA-IR index at 12 and 24 months when compared with Group B. Drospirenone containing combined oral contraceptive (COC) is found to have more favorable effects on lipid profiles, hsCRP levels, insulin resistance and hyperandrogenism when compared with the CMA containing COC and appears to be more beneficial for the long-term cardiovascular and metabo...Continue Reading

References

Aug 1, 1981·American Journal of Obstetrics and Gynecology·R HatchD Tredway
Jun 12, 2002·Fertility and Sterility·Fernando Ovalle, Ricardo Azziz
Mar 19, 2003·Current Hypertension Reports·Dalila B Corry, Michael L Tuck
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Laure Morin-PapunenJuha S Tapanainen
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
Jul 22, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D KrausJ Klein
Oct 27, 2005·The Journal of Clinical Endocrinology and Metabolism·David A EhrmannUNKNOWN PCOS/Troglitazone Study Group
Dec 17, 2005·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·P Bouchard
Aug 31, 2006·The Journal of Clinical Endocrinology and Metabolism·Ricardo AzzizUNKNOWN Androgen Excess Society
Nov 21, 2007·Human Reproduction·Teresa CascellaFrancesco Orio
Jan 28, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Stefano LelloDesanka Raskovic
May 13, 2009·Maturitas·Regine Sitruk-Ware
Jun 19, 2010·Primary Care Diabetes·Baris AkinciSena Yesil
Aug 29, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Özgür YilmazMehmet Calan
Apr 3, 2014·Clinical and Experimental Reproductive Medicine·Shahnaz TorkzahraniFatemeh Zal

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Citations

Dec 9, 2017·Reproductive Biology and Endocrinology : RB&E·Sebastião Freitas de Medeiros
Sep 26, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dinka Pavicic BaldaniMiro Kasum
Feb 20, 2018·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Mina AmiriFahimeh Ramezani Tehrani
Dec 21, 2018·The Cochrane Database of Systematic Reviews·Marian G ShowellCindy Farquhar
Mar 20, 2020·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Giuseppe MorganteVincenzo De Leo
Jun 10, 2020·Archives of Women's Mental Health·Xican YinCelia Hoi Yan Chan
Jan 1, 2019·International Journal of Inflammation·Sebastião Freitas de MedeirosMárcia Marly Winck Yamamoto
Dec 19, 2020·International Journal of Molecular Sciences·Andrea CignarellaCarla Scaroni

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