Comparison of the Effects of Continuous Subcutaneous Insulin Infusion and Add-On Therapy with Sitagliptin in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Journal of Diabetes Research
Heng WanZhi Chen

Abstract

To identify a new regimen to optimize treatment for patients with newly diagnosed type 2 diabetes (T2DM) by short-term continuous subcutaneous insulin infusion (CSII) alone. Methods. 60 patients with newly diagnosed T2DM were randomized into two groups (n = 30 each) and treated for 2 weeks with CSII alone (CSII group) or with CSII plus sitagliptin (CSII + Sig group). The glycemic variability of the patients was measured using a continuous glucose monitoring system (CGMS) for the last 72 hours. A standard meal test was performed before and after the interventions, and the levels of glycated albumin, fasting glucose, fasting C-peptide, postprandial 2 h blood glucose, and postprandial 2 h C-peptide were examined. Results. Compared with the CSII group, the indicators of glycemic variability, such as the mean amplitude of glycemic excursion (MAGE) and the standard deviation of blood glucose (SDBG), were decreased significantly in the CSII + Sig group. The changes before and after treatment in the C-peptide reactivity index (ΔCPI) and the secretory unit of islet in transplantation index (ΔSUIT) indicated a significant improvement in the CSII + Sig group. Conclusions. Add-on therapy with sitagliptin may be an optimized treatment for p...Continue Reading

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Citations

May 18, 2016·Diabetes/metabolism Research and Reviews·Zohar LandauAvivit Cahn
Nov 23, 2017·Journal of Diabetes and Metabolic Disorders·Shuang LiangXiaoquan Liu
Jul 25, 2019·Diabetes Technology & Therapeutics·Stefan PleusGuido Freckmann
Mar 19, 2019·Diabetes/metabolism Research and Reviews·Yuqian BaoUNKNOWN Chinese Diabetes Society
Oct 2, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Tomomi Ishikawa-TanakaIchiei Narita

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