Abstract
To identify a new regimen to optimize treatment for patients with newly diagnosed type 2 diabetes (T2DM) by short-term continuous subcutaneous insulin infusion (CSII) alone. Methods. 60 patients with newly diagnosed T2DM were randomized into two groups (n = 30 each) and treated for 2 weeks with CSII alone (CSII group) or with CSII plus sitagliptin (CSII + Sig group). The glycemic variability of the patients was measured using a continuous glucose monitoring system (CGMS) for the last 72 hours. A standard meal test was performed before and after the interventions, and the levels of glycated albumin, fasting glucose, fasting C-peptide, postprandial 2 h blood glucose, and postprandial 2 h C-peptide were examined. Results. Compared with the CSII group, the indicators of glycemic variability, such as the mean amplitude of glycemic excursion (MAGE) and the standard deviation of blood glucose (SDBG), were decreased significantly in the CSII + Sig group. The changes before and after treatment in the C-peptide reactivity index (ΔCPI) and the secretory unit of islet in transplantation index (ΔSUIT) indicated a significant improvement in the CSII + Sig group. Conclusions. Add-on therapy with sitagliptin may be an optimized treatment for p...Continue Reading
References
Apr 29, 1998·BMJ : British Medical Journal·R C TurnerR R Holman
Dec 14, 2001·Nature·M Brownlee
May 28, 2005·Diabetes·Michael Brownlee
Feb 3, 2006·Diabetes/metabolism Research and Reviews·Ludovica PiconiAntonio Ceriello
Jan 10, 2008·Current Medical Research and Opinion·Avraham KarasikPeter P Stein
Feb 27, 2008·Diabetes·Antonio CerielloDario Giugliano
May 1, 2008·Endocrine Journal·Kazutomi YoshiuchiMasatsugu Hori
May 15, 2008·Diabetes, Obesity & Metabolism·L XuP P Stein
May 27, 2008·Lancet·Jianping WengHua Cheng
Mar 27, 2009·The American Journal of the Medical Sciences·Daniel M RicheKrista D Riche
Apr 25, 2009·Diabetes Care·Jian ZhouWeiping Jia
Jan 23, 2010·Diabetes, Obesity & Metabolism·T VilsbøllL Katz
Feb 13, 2010·Diabetes·Kristine J HareJens J Holst
Apr 13, 2010·Diabetes, Obesity & Metabolism·L NalysnykG Krishnarajah
Jan 14, 2011·Diabetes, Obesity & Metabolism·A J TremblayP Couture
Jun 15, 2011·Evidence-based Medicine·Ebenezer Nyenwe
Mar 27, 2012·Diabetes, Obesity & Metabolism·E S HongS Lim
Jun 13, 2012·Diabetes Care·Maria Rosaria RizzoGiuseppe Paolisso
Jan 4, 2013·Endocrine·Jie ShenYajuan Han
Feb 7, 2013·Endocrine Journal·Tomoyuki KatsunoMitsuyoshi Namba
May 21, 2013·Journal of Diabetes·Yunjuan ZhaoZhiguang Zhou
Jun 6, 2013·International Journal of Endocrinology·Wen-Shan LvYan-Yan Gao
Mar 14, 2014·Endocrine Journal·Guoyue YuanChaoming Mao
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Caroline Kaercher KramerRavi Retnakaran
Jun 27, 2014·The Journal of International Medical Research·Honghong YangGuanqi Gao
Jul 22, 2015·Endocrine Journal·Guoyue YuanDong Wang
Citations
May 18, 2016·Diabetes/metabolism Research and Reviews·Zohar LandauAvivit Cahn
Nov 23, 2017·Journal of Diabetes and Metabolic Disorders·Shuang LiangXiaoquan Liu
Jul 25, 2019·Diabetes Technology & Therapeutics·Stefan PleusGuido Freckmann
Mar 19, 2019·Diabetes/metabolism Research and Reviews·Yuqian BaoUNKNOWN Chinese Diabetes Society
Oct 2, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Tomomi Ishikawa-TanakaIchiei Narita