Comparison of the effects of DMSO and pentobarbitone on experimental brain oedema

Acta neurochirurgica
H E JamesR Werner

Abstract

The purpose of this report is to compare the effect of acute therapy with dimethyl sulphoxide (DMSO) and pentobarbitone on experimental brain oedema produced by a cryogenic lesion over the left hemisphere in albino rabbits. A group of animals received DMSO (1 mg/kg-10% solution) by intravenous bolus, and another group received a pentobarbitone intravenous 30-minute infusion (40 mg/kg). Intracranial pressure (ICP), systolic arterial pressure (SAP), central venous pressure (CVP), and EEG were studied. Brain water and electrolyte content were analyzed at one hour following the initiation of therapy. ICP was promptly reduced with both forms of therapy. A 66% reduction from control values was reached at 50 +/- 12 minutes with pentobarbitone, and a 45% reduction from control values was reached at 30 minutes with DMSO. There was no significant reduction in the water content of the brain with either form of therapy. A significant elevation in brain potassium content was noted following DMSO when compared to untreated controls. CVP was essentially unchanged in both groups. Pentobarbitone produced a reduction of SAP with a mean value of 20.3 torr at 45 minutes from infusion. DMSO produced no reduction of SAP. It is concluded that DMSO an...Continue Reading

References

Dec 1, 1979·Neurosurgery·R D HarbaughR Laurin
Aug 1, 1976·British Journal of Anaesthesia·H J Reulen
Nov 1, 1976·Stroke; a Journal of Cerebral Circulation·J C de la Torre, J W Surgeon
Jul 1, 1976·Anesthesiology·A L Smith, J J Marque
Jan 1, 1975·Clinical Neurosurgery·J D Miller
Mar 1, 1973·Journal of Neurosurgery·J C de la TorreS Mullan
Jul 1, 1973·Journal of Neuropathology and Experimental Neurology·A Baethmann, A Van Harreveld
Jan 15, 1972·Biochemical Pharmacology·A W de Bruijne, J van Steveninck
Nov 1, 1973·Anesthesiology·J D Michenfelder, R A Theye
Oct 1, 1973·British Journal of Anaesthesia·H M ShapiroA B Harris
Feb 1, 1974·Experimental Neurology·K G GoF Zuiderveen
Jan 1, 1967·Journal of Neuropathology and Experimental Neurology·I KLATZO
Jul 1, 1980·Journal of Neurosurgery·F D BrownS Mullan
Nov 1, 1980·Stroke; a Journal of Cerebral Circulation·F J Schuier, K A Hossmann
Oct 1, 1958·Journal of Neuropathology and Experimental Neurology·I KLATZOE J LASKOWSKI
Oct 1, 1962·The American Journal of Physiology·A VERNADAKIS, D M WOODBURY
Jul 1, 1964·Journal of Neuropathology and Experimental Neurology·L BAKAY, I U HAQUE
Feb 1, 1971·Journal of Neurosurgery·H A WilkinsonG Austin

Citations

Jan 1, 1991·European Journal of Clinical Pharmacology·M KaracaJ C de la Torre
Jan 1, 1983·Annals of the New York Academy of Sciences·H E JamesR Werner
Jan 1, 1983·Annals of the New York Academy of Sciences·J C de la Torre
Jul 1, 1985·Equine Veterinary Journal·C J Hillidge
Mar 29, 2002·Nature Immunology·Hartmut Geiger, Gary Van Zant

Related Concepts

Metazoa
Diastolic Blood Pressure
Brain Chemistry
Vasogenic Cerebral Edema
Central Venous Pressure
Rheumabene
Intracranial Pressure
Diabutal
Chinchilla Rabbits
Water-Electrolyte Balance

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.