Comparison of the effects of dorzolamide-timolol fixed combination and brimonidine on intraocular pressure after phacoemulsification surgery

Eye & Contact Lens
Yelda OzkurtOmer K Dogan

Abstract

To compare the effects of dorzolamide-timolol combination and brimonidine on intraocular pressure (IOP) after phacoemulsification surgery. This prospective, randomized study included 69 eyes of 43 patients undergoing phacoemulsification and foldable intraocular lens implantation. Twenty-one patients were women and 22 were men. The mean patient age was 69.7+/-12.4 years. Patients were randomly assigned to one of three treatment groups preoperatively. Group A (n=23) received one drop of dorzolamide-timolol fixed combination and group B (n=23) received one drop of brimonidine tartrate 0.2% immediately after surgery. In group C (n=23), patients received no treatment and served as a control group. IOP was measured by Goldmann applanation tonometry 6 hours and 24 hours after surgery. Six hours after surgery, the mean IOP was significantly lower in group A (16.3+/-2.9 mm Hg) than in groups B (20.6+/-2.9 mm Hg) and C (24.6+/-5.4 mm Hg). However, 24 hours after surgery, the mean IOP was higher in group C (19.8+/-4.7 mm Hg) than in the other two groups (14.1+/-2.8 mm Hg in group A and 17.5+/-2.7 mm Hg in group B). Prophylactic treatment with dorzolamide-timolol fixed combination was more effective than brimonidine in reducing IOP 6 hours...Continue Reading

References

Nov 18, 1998·Journal of Cataract and Refractive Surgery·S Byrd, K Singh
Apr 20, 2001·Journal of Cataract and Refractive Surgery·B J ShingletonH Hoey
Nov 9, 2001·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·O SchwennH B Dick
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Jan 8, 2004·Journal of Cataract and Refractive Surgery·John M KatsimprisNikolaos Georgiadis

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Citations

Jan 19, 2011·Journal of Cataract and Refractive Surgery·Nikolaos PharmakakisConstantine D Georgakopoulos
Feb 26, 2013·Clinical & Experimental Ophthalmology·Constantine D GeorgakopoulosNikolaos Pharmakakis
Dec 3, 2014·Archivos de la Sociedad Española de Oftalmología·I Rodríguez UñaUNKNOWN Grupo Español para el Consenso acerca del Manejo Farmacológico Perioperatorio en pacientes con glaucoma

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