PMID: 2508153Jan 1, 1989Paper

Comparison of the effects of four cholinomimetic agents on cognition in primates following disruption by scopolamine or by lists of objects

Psychopharmacology
N M RupniakS D Iversen

Abstract

The ability of four central cholinomimetics to reverse a scopolamine-induced spatial memory impairment or to improve visual recognition memory in primates was examined. Physostigmine (0.04-0.08 mg/kg IM) fully reversed the effects of scopolamine (0.03 mg/kg). Coadministration of pilocarpine (3.0-5.0 mg/kg) caused partial reversal of the scopolamine impairment after intermediate or long retention intervals (10 or 20 s). Treatment with arecoline (0.1-1.8 mg/kg) or nicotine (1.0-2.0 mg/kg) generally did not reverse the effects of scopolamine. A task in which memory could be taxed by increasing the number of visual stimuli presented appeared more sensitive to the effects of cholinomimetics on cognition than the scopolamine reversal model. In this paradigm treatment with physostigmine (0.001, 0.01 or 0.03 mg/kg) increased choice accuracy from about 55 to 70% correct. Arecoline improved performance at one dose only (0.1 mg/kg) which also induced marked adverse side-effects (salivation and tremor). Pilocarpine improved performance in the dose range 0.125-0.35 mg/kg, but not at higher doses which also induced marked salivation. Treatment with nicotine (0.001-2.0 mg/kg tended to improve performance but this did not reach statistical sig...Continue Reading

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Citations

Jan 1, 1990·Psychopharmacology·N M RupniakS D Iversen
Jan 1, 1992·Psychopharmacology·D K Rush, K Streit
Jan 1, 1992·Psychopharmacology·E D Levin
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·A M BrattB Costall
Sep 1, 1992·Behavioral and Neural Biology·E D LevinJ E Rose
Mar 1, 1993·Neurobiology of Aging·M J CallahanR E Davis
Jan 1, 1997·Life Sciences·S D Iversen
Mar 30, 2001·Schizophrenia Research·R M KirraneL J Siever
Oct 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carrie K JonesMichael Bubser
Nov 21, 1998·European Journal of Clinical Investigation·U Ebert, W Kirch
Jun 15, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Muhammad Nabeel GhayurAnwarul Hassan Gilani
Nov 27, 2010·Behavioural Brain Research·Serena DeianaGernot Riedel
Nov 1, 2006·The European Journal of Neuroscience·Changqing XuMeenakshi Alreja
Mar 23, 2011·Behavioural Brain Research·Caroline ChambonWojciech Danysz
Jan 1, 1994·Journal of Psychopharmacology·J H Jansen, J S Andrews
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ilga Misane, Sven Ove Ogren
Apr 11, 2019·Journal of Medical Primatology·Lisa M Wooldridge, Brian D Kangas
Sep 26, 2015·Pharmacological Reviews·Esa R KorpiGavin S Dawe

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