PMID: 11932952Apr 5, 2002Paper

Comparison of the effects of HGF, BDNF, CT-1, CNTF, and the branchial arches on the growth of embryonic cranial motor neurons

Journal of Neurobiology
Arifa NaeemS Guthrie

Abstract

In the developing embryo, axon growth and guidance depend on cues that include diffusible molecules. We have shown previously that the branchial arches and hepatocyte growth factor (HGF) are growth-promoting and chemoattractant for young embryonic cranial motor axons. HGF is produced in the branchial arches of the embryo, but a number of lines of evidence suggest that HGF is unlikely to be the only factor involved in the growth and guidance of these axons. Here we investigate whether other neurotrophic factors could be involved in the growth of young cranial motor neurons in explant cultures. We find that brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF) and cardiotrophin-1 (CT-1) all promote the outgrowth of embryonic cranial motor neurons, while glial cell line-derived neurotrophic factor (GDNF) and neurotrophin-3 (NT-3) fail to affect outgrowth. We next examined whether HGF and the branchial arches had similar effects on motor neuron subpopulations at different axial levels. Our results show that HGF acts as a generalized rather than a specific neurotrophic factor and guidance cue for cranial motor neurons. Although the branchial arches also had general growth-promoting effects on all motor neuron ...Continue Reading

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Citations

Oct 11, 2003·Molecular and Cellular Neurosciences·Jennifer ChenChristopher S von Bartheld
Jan 25, 2012·International Journal of Molecular Sciences·Arlene Bravo-Ambrosio, Zaven Kaprielian
Mar 18, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jia-jun XuCheng He
Jan 12, 2011·The European Journal of Neuroscience·Kenta KobayashiKazuto Kobayashi
Mar 5, 2014·Journal of Anatomy·E De FeliceP Sordino
Feb 12, 2015·Journal of Neuroimmunology·Minako BeppuSatoshi Kuwabara
Dec 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Anand Chandrasekhar
Oct 20, 2007·Nature Reviews. Neuroscience·Sarah Guthrie
May 23, 2014·Journal of Neurophysiology·Yang LiuChristine K Thomas
Dec 6, 2019·Experimental Brain Research·Lianlian LiRuijin Huang
Jun 25, 2017·Scientific Reports·Luís F MartinsRamiro D Almeida
Feb 4, 2021·Stem Cells Translational Medicine·Jennifer SotoSong Li

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