PMID: 3768733Aug 1, 1986Paper

Comparison of the effects of hypercapnia on phrenic and hypoglossal activity in anesthetized decerebrate and decorticate animals

Brain Research Bulletin
J MitraN S Cherniack

Abstract

To examine the effects of suprapontine structures on the activity of hypoglossal and phrenic nerves, 13 chloralose anesthetized, paralyzed (gallamine triethiodide) and artificially ventilated cats were studied. In all animals vagi and carotid sinus nerves were cut bilaterally. All animals were first hyperventilated to apnea and then made progressively hypercapnic by rebreathing under hyperoxic conditions. Following midcollicular decerebration, the peak phasic activity of the hypoglossal nerve was significantly depressed and the PCO2 at which apnea occurred (apneic point) increased. However, following high decerebration or decortication the activity of the hypoglossal nerve was increased at higher CO2 levels and there was no change in apneic point. By contrast, peak phrenic nerve activity was not altered by any of the above surgical procedures. Neither systemic blood pressure nor respiratory frequency were significantly altered by these procedures. The results indicate that suprapontine structures can appreciably modify hypoglossal activity.

References

Feb 1, 1977·Respiration Physiology·S M Tenney, L C Ou
Jun 1, 1971·The Journal of Comparative Neurology·P Brodal
Jun 1, 1971·The Journal of Comparative Neurology·P Brodal
Jun 1, 1971·Respiration Physiology·R S Fitzgerald, D C Parks
Jan 1, 1970·Pflügers Archiv : European journal of physiology·T Sumi
May 1, 1984·Respiration Physiology·W M St JohnK E Rist

❮ Previous
Next ❯

Citations

Mar 1, 1991·Pflügers Archiv : European journal of physiology·T G Waldrop
May 1, 1993·Respiration Physiology·I R CookeP J Berger
Dec 1, 1991·Journal of the Autonomic Nervous System·P G WagnerR T Dowell
Jan 1, 1992·Brain Research Bulletin·C A PeanoT G Waldrop
Nov 1, 1996·Respiration Physiology·C R Richmonds, D W Hudgel
Oct 17, 1998·Respiration Physiology·S IscoeJ Duffin
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·J A RowleyA R Schwartz
Sep 6, 2005·American Journal of Respiratory and Critical Care Medicine·Jooby JohnRalph F Fregosi
May 12, 2011·Respiratory Physiology & Neurobiology·E Fiona Bailey
Mar 8, 2011·Respiratory Physiology & Neurobiology·Kun-Ze Lee, David D Fuller
Oct 24, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A J Miller
May 15, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A Sawczuk, K M Mosier
Aug 11, 2007·Journal of Applied Physiology·R El Hasnaoui-SaadaniF Favret
Oct 5, 2013·Journal of Applied Physiology·Ralph F Fregosi, Christy L Ludlow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.