PMID: 9555999Apr 29, 1998Paper

Comparison of the effects of ischemic preconditioning and surgical delay on pedicled musculocutaneous flap survival in a rat model

Annals of Plastic Surgery
K S ZahirJ G Thomson

Abstract

Both surgical delay (SD) and ischemic preconditioning (IP) have been shown to be effective in improving the survival of pedicled musculocutaneous flaps. The goal of our study was to determine the effects of IP and SD, separately and together, on the survival of pedicled transverse rectus abdominis musculocutaneous (TRAM) flaps in a rat model. Thirty-two male Sprague-Dawley rats were divided into four groups of 8 rats each: (1) control, (2) 2-week SD, (3) IP, and (4) SD plus IP. A TRAM flap was elevated in each rat. Flap viability was assessed on the fifth postoperative day by computerized video planimetry. Mean area of flap survival was compared between the control, IP, SD, and SD plus IP groups using analysis of variance and Student's t-test. Improvement in surface area survival was seen in musculocutaneous flaps subjected to IP, SD, and SD plus IP compared with the control. IP and SD improved survival 1.3 and 1.4 times the control area respectively. Differences between treatment and control flaps were statistically significant (p < 0.04). In addition, the combination of SD plus IP improved survival by 1.8 times, which is statistically different from controls and from either technique individually (p < 0.002). IP and SD have s...Continue Reading

Citations

Nov 18, 2000·Plastic and Reconstructive Surgery·V Macionis
Apr 5, 2002·Plastic and Reconstructive Surgery·Chris WanJohn H Barker
Apr 4, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Gülsüm Tetik MenevşeIbrahim Tekdemir
Apr 16, 2013·The Journal of Surgical Research·Mickaël TobalemYves Harder
Jan 2, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Y HarderM D Menger
Dec 21, 2000·British Journal of Plastic Surgery·H MatsumuraK Watanabe
Sep 4, 2012·The Journal of Hand Surgery·Ole GoertzHans U Steinau
Apr 14, 2016·Journal of Plastic Surgery and Hand Surgery·Arzu AkcalSoner Tatlidede
Sep 26, 2006·Annals of Plastic Surgery·O Koray CoskunfiratMustafa B Dikici
Mar 10, 2006·Plastic and Reconstructive Surgery·Alizan A KhalilJohn C Hall
Apr 19, 2007·Plastic and Reconstructive Surgery·Shadi GhaliGeoffrey C Gurtner
Apr 1, 2000·The Journal of Trauma·M H ChengE Brey
Oct 30, 2009·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Birol CivelekSelim Celebioglu
Feb 26, 2020·Plastic and Reconstructive Surgery. Global Open·Andreas E KragBirgitte J Kiil

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