Comparison of the effects of isoflurane with those of propofol on pulmonary vascular impedance in experimental embolic pulmonary hypertension

British Journal of Anaesthesia
P EwalenkoRobert Naeije

Abstract

Inhaled but not i.v. anaesthetics are reported to decrease pulmonary vascular resistance. The aim of this study was to compare the effects of isoflurane with those of propofol on the interaction between right ventricular (RV) function and the pulmonary vascular system in embolic pulmonary hypertension. Nine dogs received in random sequence propofol 18 mg kg-1 h-1 and 1.4% end-tidal isoflurane. Pulmonary haemodynamic state was evaluated by pulmonary arterial pressure/flow (PAP/Q) plots and pulmonary vascular impedance (PVZ) spectra. Right ventricular function was assessed by total hydraulic power (Wtot), ratio of oscillatory power (Wosc) to Wtot, and dP/dtmax. Measurements were obtained, with both anaesthetics, before and after pulmonary embolic hypertension induced by autologous blood clots. Embolism increased PAP, 0 Hz and low frequency input impedance, displaced first minimum of PAP/Q moduli and zero crossing of phase to higher frequencies, decreased characteristic impedance, decreased Wosc/Wtot without affecting Wtot, and increased dP/dtmax. Compared with propofol, isoflurane at baseline did not affect PAP/Q plots, PVZ or hydraulic power data, but decreased dP/dtmax. After embolism, isoflurane shifted PAP/Q plots to lower PA...Continue Reading

Citations

Mar 29, 2006·Annals of Biomedical Engineering·Holly A TuchschererNaomi C Chesler
Jun 15, 2007·Critical Care Medicine·François KerbaulFrédéric Collart
Dec 15, 2012·American Journal of Respiratory Cell and Molecular Biology·M Patricia GeorgeKaren A Norris
Dec 1, 2009·Annales Françaises D'anesthèsie Et De Rèanimation·W NaijaA Mebazaa
May 23, 2003·Anesthesia and Analgesia·Lars G FischerHartmut Bu Combining Diaeresis Rkle
May 31, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Kathirvel Subramaniam, Jean-Pierre Yared
Feb 6, 2021·Clinics in Chest Medicine·Inderjit SinghJennifer Haythe

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