PMID: 18719746Aug 23, 2008Paper

Comparison of the effects of lactated Ringer solution with and without hydroxyethyl starch fluid resuscitation on gut edema during severe splanchnic ischemia

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
S M LoboP M Cury

Abstract

The type of fluid used during resuscitation may have an important impact on tissue edema. We evaluated the impact of two different regimens of fluid resuscitation on hemodynamics and on lung and intestinal edema during splanchnic hypoperfusion in rabbits. The study included 16 female New Zealand rabbits (2.9 to 3.3 kg body weight, aged 8 to 12 months) with splanchnic ischemia induced by ligation of the superior mesenteric artery. The animals were randomized into two experimental groups: group I (N = 9) received 12 mL x kg-1 x h-1 lactated Ringer solution and 20 mL/kg 6% hydroxyethyl starch solution; group II (N = 7) received 36 mL x kg-1 x h-1 lactated Ringer solution and 20 mL/kg 0.9% saline. A segment from the ileum was isolated to be perfused. A tonometric catheter was placed in a second gut segment. Superior mesenteric artery (Q SMA) and aortic (Qaorta) flows were measured using ultrasonic flow probes. After 4 h of fluid resuscitation, tissue specimens were immediately removed for estimations of gut and lung edema. There were no differences in global and regional perfusion variables, lung wet-to-dry weight ratios and oxygenation indices between groups. Gut wet-to-dry weight ratio was significantly lower in the crystalloid/c...Continue Reading

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Citations

Feb 26, 2011·Der Anaesthesist·B NohéK Unertl
Sep 29, 2011·Critical Care : the Official Journal of the Critical Care Forum·Suzana M LoboFrancisco R Lobo
Mar 20, 2009·Current Opinion in Anaesthesiology·Matthias JacobMarkus W Hollmann
Mar 2, 2013·The Cochrane Database of Systematic Reviews·Pablo PerelKatharine Ker
May 8, 2021·The American Journal of the Medical Sciences·Xinchen Wang, Dawei Liu

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