Comparison of the Effects of Melatonin and Oxazepam on Anxiety Levels and Sleep Quality in Patients With ST-Segment-Elevation Myocardial Infarction Following Primary Percutaneous Coronary Intervention: A Randomized Clinical Trial

The Annals of Pharmacotherapy
Padideh GhaeliAzita Hajhossein Talasaz

Abstract

Anxiety and sleep disorders are prevalent problems in patients presenting with ST-segment-elevation myocardial infarction (STEMI). Usually, these problems are managed by benzodiazepines, which-albeit effective-could cause adverse effects and drug interaction. This study was designed to compare the effects of melatonin and oxazepam in the management of anxiety and insomnia on patients following primary percutaneous coronary intervention (PCI) with a view to providing a safer alternative. This study was designed as a randomized clinical trial. STEMI patients managed with primary PCI were enrolled and randomized into 2 groups through the permuted block randomization. The patients received either oxazepam (10 mg) or melatonin (3 mg) every night. Autoimmune disease or previous use of psychoactive medications was considered the exclusion criterion. Levels of anxiety and sleep quality were evaluated using the Hamilton Anxiety Rating Scale (HAM-A) and the Groningen Sleep Quality Score and compared between the groups. Each group contained 20 patients. Melatonin showed a significant advantage over oxazepam in improving sleep quality ( P = 0.040). Comparisons of the efficacy of both medications in lowering the anxiety levels when consider...Continue Reading

References

Jul 1, 1977·The Medical Clinics of North America·N H Cassem, T P Hackett
Mar 1, 1995·Clinical Endocrinology·S M Webb, M Puig-Domingo
Oct 1, 1994·Sleep·O Tzischinsky, P Lavie
Mar 1, 1996·Heart & Lung : the Journal of Critical Care·J M CroweD L Streiner
Jun 1, 1997·The American Journal of Cardiology·M C CohenM A Mittleman
Feb 9, 2000·Archives of Internal Medicine·D GarfinkelM Laudon
Apr 2, 2003·Cardiovascular Research·Russel J Reiter, Dun-Xian Tan
May 3, 2003·International Journal of Cardiology·Mevlut YaprakGultac Ozbay
Nov 5, 2003·British Journal of Health Psychology·Deirdre LaneGregory Y H Lip
Mar 17, 2004·Heart & Lung : the Journal of Critical Care·Kyungeh AnDebra K Moser
Jan 15, 2005·Sleep Medicine Reviews·Bruno ClaustratGuy Chazot
Apr 12, 2005·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Thomas Giles
Dec 27, 2005·The American Journal of Cardiology·Alberto Dominguez-RodriguezJuan Carlos Kaski
Sep 27, 2006·The American Journal of Medicine·Ehud GrossmanNava Zisapel
Sep 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Hikmet Yilmaz, Ihsan Iskesen
Dec 7, 2007·Atherosclerosis·Alberto Dominguez-RodriguezJuan Carlos Kaski
Nov 26, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D M NunesP F C de Bruin
Dec 1, 2010·The Journal of Cardiovascular Nursing·Jia-Rong WuLynn V Doering
Nov 18, 2011·The Journal of Nursing Research : JNR·Wen-Chun LiaoShiow-Li Hwang
Dec 19, 2012·Circulation·Patrick T O'GaraUNKNOWN American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Jul 15, 2015·Neurosciences : the Official Journal of the Pan Arab Union of Neurological Sciences·Hacı A SariarslanSenol Delibas

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation
coronary artery bypass
Pharmacotherapy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.