PMID: 1206813Aug 1, 1975Paper

Comparison of the effects of norepinephrine and acetylcholine between intraarterial and extravascular administration to the isolated, blood-perfused canine atrium

Japanese Journal of Pharmacology
S ChibaK Hashimoto

Abstract

Effects of acetylcholine (ACh) and norepinephrine on atrial contractility and pacemaker activity were investigated in isolated and blood-perfused canine atrium preparations whith a support dog which were suspended in the blood-filled bath kept at 37 degrees C. The drug was given in two forms of administration, i.e., intraarterial injection into the cannulated sinus node artery or direct administration into the bath. ACh administered into the bath produced a significant decrease in the developed tension from a concentration of 10(-5) g/ml and norepinephrine produced a significant increase in the developed tension from 3 X 10(-6) g/ml. An injection via the sinus node artery resulted in 300 and 100 times greater response to ACh and norepinephrine, respectively, in the tension development. In atrial pacemaker activity, ACh given into the bath did not produce a dose-related decrease while norepinephrine produced a dose-related increase frequently accompanied by an irregularity of rhythmicity.

Citations

Mar 1, 1980·Clinical and Experimental Pharmacology & Physiology·S ChibaM Kobayashi
Mar 1, 1981·Clinical and Experimental Pharmacology & Physiology·S ChibaY Furukawa
Jan 1, 1983·Clinical and Experimental Pharmacology & Physiology·S Chiba, H Watanabe
Sep 23, 2000·Japanese Journal of Pharmacology·M Tsuboi, S Chiba
Nov 1, 1977·Clinical and Experimental Pharmacology & Physiology·S Chiba
Sep 1, 1978·Clinical and Experimental Pharmacology & Physiology·S Chiba
Mar 1, 1976·Clinical and Experimental Pharmacology & Physiology·S Chiba
Jun 30, 2000·Clinical and Experimental Pharmacology & Physiology·M Tsuboi, S Chiba
Feb 1, 1980·Japanese Journal of Pharmacology·S ChibaM Kobayashi

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