PMID: 9457495Feb 11, 1998

Comparison of the effects of NS-21 and terodiline on the QTc interval in dogs

General Pharmacology
T NatsukawaK Kimura

Abstract

1. NS-21 [(+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate], its active metabolite, RCC-36, and terodiline, are mixed anticholinergic-Ca2+ antagonistic drugs. Among them, terodiline has been shown to cause torsade de pointes, a serious polymorphic ventricular tachycardia. It remains unknown, however, whether NS-21 or its active metabolite, RCC-36, produces torsade de pointes. 2. In anesthetized dogs, terodiline (10 mg/kg i.v.) significantly prolonged the QTc interval by 6-8%, an effect thought to be associated with torsade de pointes. In contrast, neither NS-21 nor RCC-36 (10 mg/kg i.v.) prolonged the QTc interval; therefore NS-21 is unlikely to cause ventricular tachyarrhythmias, such as those associated with terodiline. 3. The effects of NS-21, RCC-36 and terodiline on the action potential were investigated in guinea pig papillary muscle. However, none of these drugs prolonged the duration of the action potential, although only terodiline caused the muscle preparation to lose its excitability.

References

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Citations

Mar 19, 2002·American Journal of Therapeutics·Robert R Fenichel

Related Concepts

Terodiline hydrochloride
4-ethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride
Butylamines
Calcium Channel Blockers
Canis familiaris
Dose-Response Relationship, Drug
Electrocardiographic Recorders
Electrophysiology (Science)
Cavia porcellus
Phenylacetic Acids

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