Comparison of the effects of proton pump inhibitors on human plasma adrenocorticotropic hormone and cortisol levels under the starved condition

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Fumihiko KatagiriMasaharu Takeyama

Abstract

The hypothalamo-pituitary-adrenal (HPA) axis is known to relate with energy homeostasis. Appetite and food intake are assumed to be regulated by the HPA axis. Among lots of medicines that act gastrointestinal system, we focused proton pump inhibitors, which are widely used to treat peptic ulcer, gastro esophageal reflux disease and eradication of Helicobacter pylori. In this study, we investigated that the effect of three proton pump inhibitors (omeprazole, lansoprazole and rabeprazole) on plasma adrenocorticotropic hormone (ACTH) and cortisol levels in healthy human subjects. Five healthy male volunteers were treated to omeprazole, lansoprazole, rabeprazole or placebo. Venous blood samples were taken repetitively from a forearm vein before and after administration. Plasma ACTH-like immunoreactive substance (IS) levels were measured using a sensitive enzyme immunoassay, and plasma cortisol levels were measured using a fluorescence polarization immunoassay. Single administration of lansoprazole caused significant (P<0.05) increase of ACTH-IS at 60 and 120-180 min, and cortisol at 180-240 min after administration, compared with placebo group. Rabeprazole also caused significant increase of ACTH-IS at 120 min and cortisol at 240-3...Continue Reading

References

Jan 1, 1988·European Journal of Clinical Pharmacology·L J DowieC J Kenyon
Sep 1, 1982·Annals of Internal Medicine·A PontD A Stevens
May 20, 2000·Neuropharmacology·I A AntonijevicA Steiger
Feb 7, 2003·Life Sciences·Robert T RubinR Kenneth Czambel

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Citations

Nov 21, 2008·Biophysical Chemistry·Ana Paula Romani, Amando Siuiti Ito
Nov 15, 2016·Gastroenterology Research and Practice·Wang-Ping MengMu-Han Lü

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