PMID: 6109686Jan 1, 1981Paper

Comparison of the effects of ranitidine, cimetidine and placebo on the 24 hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer

Gut
R P WaltJ J Misiewicz

Abstract

Twenty-four hour intragastric acidity and nocturnal acid secretion were measured in 10 males with duodenal ulcer in four separate 24 hour studies, during which the subjects ate normal meals, had unrestricted physical activity, and consumed their customary quantities of tobacco. The medication consisted of either placebo, cimetidine 200 mg tds and 400 mg at night, or ranitidine 150 mg bd, or 200 mg bd. Ranitidine 150 mg bd decreased mean 24 hour hydrogen ion activity from 41.8 mmol/l to 13.1 mmol/l (-69%, P less than 0.001) and nocturnal acid output from 6.1 mmol/h to 0.6 mmol/h (-90%, P less than 0.01). This degree of inhibition was significantly greater than that due to cimetidine (P less than 0.001 for 24 hours acidity, less than 0.05 for night time acid output). Plasma concentrations of ranitidine were greater than the IC50 for more than eight hours after the 150 mg dose. Ranitidine 200 mg conferred no additional advantage. Ranitidine 150 mg bd should be tested in therapeutic trials.

Citations

Jan 1, 1984·European Journal of Clinical Pharmacology·E J Boyd, K G Wormsley
Jan 1, 1984·European Journal of Clinical Pharmacology·V F EckardtH Wiemann
Jul 1, 1983·Digestive Diseases and Sciences·J BelaicheJ Yvart
Feb 1, 1982·Digestive Diseases and Sciences·H G DammannB Simon
Feb 16, 1987·Klinische Wochenschrift·H KoopR Arnold
Dec 1, 1987·Agents and Actions·P PinelliR Cavallaro
Aug 1, 1995·Digestive Diseases and Sciences·M J Collen, J F Wirshup
Jan 1, 1984·Pharmacology & Therapeutics·R E Pounder
Dec 5, 1981·Lancet·P I ReedF R House
Mar 14, 1981·Lancet·R F McCloy, J H Baron
Mar 14, 1981·Lancet·M L WilkinsonT J Kiernan
Jan 23, 1982·Lancet·M Gracey Sunoto
Dec 10, 1983·Lancet·J J StanekH Ellis
Dec 10, 1983·Lancet·T GledhillR H Hunt
Dec 10, 1983·Lancet·G H BurtonT D Tetley
Jul 1, 1988·Baillière's Clinical Gastroenterology·R Pounder
Jul 15, 1998·Alimentary Pharmacology & Therapeutics·T G ReillyC U Nwokolo
Dec 1, 1983·The New England Journal of Medicine·J B ZeldisK J Isselbacher
May 1, 1996·Clinical and Experimental Pharmacology & Physiology·S L ElliottN D Yeomans
Apr 1, 1995·Journal of Paediatrics and Child Health·M McDonnell, N Evans
Jul 2, 1983·British Medical Journal·R P WaltR E Pounder
Nov 24, 1984·British Medical Journal·I A SantanaM Talbot
Jul 1, 1984·Gut·R E Pounder

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