PMID: 6107406Sep 20, 1980Paper

Comparison of the effects of regular and enteric-coated aspirin on gastroduodenal mucosa of man

Lancet
J W HoftiezerK J Ivey

Abstract

To determine whether the topical or systemic effects of aspirin are of greater importance in the production of gastroduodenal mucosal damage, the effects of regular and enteric-coated aspirin were compared in 9 healthy volunteers in a 2-week crossover endoscopic study. All subjects developed multiple gastric erosions while taking regular aspirin; 2 subjects developed one gastric erosion each while taking enteric-coated aspirin. 5 subjects developed duodenal erosions while taking regular aspirin, whereas none developed an erosion while taking enteric-coated aspirin. Mean fasting salicylate levels were similar in the two groups. It is concluded that regular aspirin causes a greater amount of gastroduodenal mucosal damage than does enteric-coated aspirin despite similar serum-salicylate levels. This suggests that the topical effects of aspirin are of greater importance than the systemic effects in the production of gastroduodenal mucosal damage in healthy subjects.

References

Dec 1, 1977·Annals of Internal Medicine·P A MacKercherW J Krause
Oct 1, 1979·Annals of Internal Medicine·G R SilvosoJ Hewett
Apr 1, 1972·Gut·K G Wormsley
Oct 9, 1970·Science·D A BrodieK F Hooke

❮ Previous
Next ❯

Citations

Feb 1, 1986·Digestive Diseases and Sciences·F E SilversteinD S Levine
Jan 1, 1983·Digestive Diseases and Sciences·D Y GrahamS M Dobbs
Feb 18, 2011·European Journal of Clinical Pharmacology·Rosa M AntonijoanManel J Barbanoj
Nov 26, 2009·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Bita GeramizadehBabak Banan
Aug 1, 1982·Prostaglandins, Leukotrienes, and Medicine·M M Cohen, W C MacDonald
Jun 3, 2000·Gastroenterology Clinics of North America·H HussainM S Cappell
Dec 12, 2001·British Journal of Clinical Pharmacology·L A García RodríguezF J de Abajo
Sep 1, 1999·Alimentary Pharmacology & Therapeutics·H G DammannN Wolf
Jan 1, 1994·Journal of Gastroenterology and Hepatology·N D YeomansA S Giraud
Jul 1, 1996·The Journal of Pharmacy and Pharmacology·G Chandrashekar, N Udupa
Oct 10, 1981·British Medical Journal·S M Gore
Sep 1, 1993·Postgraduate Medical Journal·R OrenJ Zimmerman
Nov 26, 2004·British Journal of Clinical Pharmacology·Jan C BeckerThorsten Pohle
Aug 14, 2003·Fundamental & Clinical Pharmacology·Michael J S Langman
Apr 8, 2004·Journal of Clinical Pharmacy and Therapeutics·M TakadaM Shibakawa
Jan 30, 2007·Current Medical Research and Opinion·Angel Lanas, James Scheiman
Dec 8, 2010·Scandinavian Journal of Gastroenterology·Akiko ShiotaniKen Haruma
Aug 1, 1991·Scandinavian Journal of Gastroenterology·L Aabakken
Jan 1, 1995·Arthritis and Rheumatism·D R LichtensteinM M Wolfe
Jan 1, 1983·Scandinavian Journal of Rheumatology·J Martio, P Kahela
Jan 31, 2002·The Annals of Pharmacotherapy·Dalia W BanoobWilliam Webster
Feb 14, 2014·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·J Jaspers FocksM G H van Oijen
Jul 1, 1984·Biopharmaceutics & Drug Disposition·L BorgströmE Wåhlin-Boll
Sep 28, 2000·The American Journal of Gastroenterology·H T SørensenJ H Olsen
Jan 1, 1986·Biopharmaceutics & Drug Disposition·P R Montgomery, D S Sitar
Jan 10, 1981·British Medical Journal
Jul 16, 2019·Expert Review of Cardiovascular Therapy·Michael E PlazakStormi E Gale
Dec 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R M Botting
Dec 1, 1992·Scandinavian Journal of Gastroenterology·L AabakkenM Osnes
Sep 1, 1993·Journal of the American Geriatrics Society·R C Deckmann, L J Cheskin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.