Comparison of the effects of RNase-negative and wild-type classical swine fever virus on peripheral blood cells of infected pigs

The Journal of General Virology
Martina von FreyburgG Meyers

Abstract

Elimination of the RNase activity of classical swine fever virus (CSFV) glycoprotein E(rns) was previously shown to result in virus attenuation. Specific reduction of B cell numbers in the peripheral blood, a typical symptom of CSFV infection in pigs, was not detected on infection with the RNase-negative mutant C-H346Delta [Meyers et al. (1999). J Virol 73, 10224-10235]. The present report shows that this feature is restricted to this specific virus mutant, and does not represent a general property of RNase-negative CSFV. The effects induced by infection with two other RNase-negative and wild-type (wt) CSFV strains on the composition of peripheral blood cells have been further analysed. For all viruses, not only general leukopenia but also a reduction of different subsets of leukocytes (T-lymphocytes, monocytes and granulocytes) was detected. Similar to the results with B-cells, no significant differences with regard to changes in cell number were determined for RNase-negative mutants and wt virus during the initial phase of infection. Later, the values returned to pre-infection levels for the mutants, but stayed at low levels in the wt virus-infected animals. A major difference was reflected in the virus load of the infected a...Continue Reading

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Citations

Aug 9, 2012·Biologicals : Journal of the International Association of Biological Standardization·Ernst Peterhans, Matthias Schweizer
Mar 2, 2010·Trends in Biochemical Sciences·Natalie Luhtala, Roy Parker
Oct 23, 2009·Veterinary Microbiology·Ernst Peterhans, Matthias Schweizer
Feb 26, 2016·Canadian Journal of Microbiology·Yan LiMingwang Zhang
Apr 8, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth ReidJulian Seago
Jul 24, 2021·Scientific Reports·Bjoern PetersenGregor Meyers

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