Comparison of the effects of telmisartan and olmesartan on home blood pressure, glucose, and lipid profiles in patients with hypertension, chronic heart failure, and metabolic syndrome

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Tatsuya SasakiKunio Miyatake

Abstract

We compared the effects of telmisartan and olmesartan in 20 patients with chronic heart failure and metabolic syndrome. The subjects underwent once-daily 40 mg telmisartan for at least 3 months before switching to once-daily 20 mg olmesartan for the next 3 months (post 1). They were then treated with 3 months of once-daily 40 mg telmisartan (post 2). Systolic and diastolic blood pressure in the early morning, plasma B-type natriuretic peptide, serum total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels were increased at post 1 (p < 0.005, p < 0.05, p < 0.05, p < 0.05, p < 0.05, and p < 0.005 vs. baseline, respectively) before returning to their baseline values at post 2. The changes in plasma B-type natriuretic peptide levels correlated significantly with the shifts in systolic and diastolic blood pressure in the early morning at posts 1 and 2. Meanwhile, there were no fluctuations in either blood pressure in the late evening or in the outpatient room; nor were there fluctuations in heart rate. Simultaneously, neither serum high-density lipoprotein cholesterol nor fasting blood sugar levels differed significantly between posts. Moreover, telmisartan had more beneficial effects on glucose and lipid prof...Continue Reading

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Citations

Feb 28, 2009·World Journal of Gastroenterology : WJG·Eugen Florin GeorgescuLiliana Vancica
May 8, 2010·Vascular Health and Risk Management·Domenico GalzeranoCarlo Gaudio
Jul 7, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Shin-ichiro MiuraKeijiro Saku
Nov 28, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shin-Ichiro Miura, Keijiro Saku
Aug 3, 2011·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Giuliano TocciMassimo Volpe

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