PMID: 9555118Apr 29, 1998Paper

Comparison of the effects of the antimetastatic compound ImH[trans-RuCl4(DMSO)Im] (NAMI-A) on the arthritic rat and on MCa mammary carcinoma in mice

Pathology Oncology Research : POR
G SavaR Milanino

Abstract

The effects of the new molecule ImH[trans-RuCl4(DMSO)Im] (NAMI-A), administered orally or intraperitoneally to adjuvant-arthritic rats or orally to mice bearing s.c. or i.m. implants of MCa mammary carcinoma, were studied. NAMI-A was not able to modify the progression of chronic inflammation in the complete Freund-adjuvant injected animals. Histology indicated a significant worsening of the inflammatory process, characterised by an increased infiltration of inflammatory cells, as well as by a remarkable deposition of connective tissue fibres around the blood vessels and alveolar walls. NAMI-A had no effect on primary i.m. implanted MCa mammary carcinoma growth and its lung metastasis formation, but significantly interfered with the cell cycle of primary tumor cells following bolus oral administration. On the contrary, NAMI-A caused a significant inhibition of lung metastasis accompanied by a dramatic deposition of connective tissue fibres around the primary tumor mass, when given as medicated food to mice implanted s.c. with MCa tumor. These data indicated that NAMI-A is well absorbed after oral administration although there is no connection between lung concentration and the antimetastatic activity. Conversely, the marked depo...Continue Reading

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Citations

Jun 1, 2009·Future Medicinal Chemistry·Simon M PagePaul D Barker
Nov 4, 2000·Expert Opinion on Investigational Drugs·D R Richardson, D B Lovejoy
Feb 5, 2010·Journal of Enzyme Inhibition and Medicinal Chemistry·Sreekanth ThotaErik De Clercq
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Nov 9, 2019·Chembiochem : a European Journal of Chemical Biology·Liam J StephensPhilip C Andrews
Apr 11, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Venugopal RajendiranMallayan Palaniandavar
Mar 2, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Sethu RamakrishnanMallayan Palaniandavar
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Sep 4, 2007·Bioorganic & Medicinal Chemistry·Subhas S KarkiErik De Clercq
Dec 26, 2001·Chemical Reviews·M J ClarkeD R Frasca
Apr 29, 2021·Inorganic Chemistry·Pran Gobinda NandiAkshai Kumar
Jun 10, 2005·Journal of Medicinal Chemistry·Claudine ScolaroPaul J Dyson

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