PMID: 6103937Mar 1, 1980Paper

Comparison of the effects of the stereoisomers of fenfluramine on the acetylcholine content of rat striatum, hippocampus and nucleus accumbens

The Journal of Pharmacy and Pharmacology
S ConsoloS Garattini

Abstract

The (+)- and (-)- isomeric forms of fenfluramine were compared for their effects on rat brain area acetylcholine (ACh) content. The drugs showed similar patterns in increasing ACh content in the accumbens and hippocampus and in being ineffective in the brainstem. The actions differed in the striatum where the (+)-form markedly increased ACh content while the (-)-form produced no change. Both isomer-induced increases in ACh in the accumbens were prevented when 5-HT synthesis was blocked by p-chlorophenylalanine, thus denoting 5-hydroxytryptaminergic mediation of these effects. In striatum, the increase in ACh induced by (+)-fenfluramine was summated with the increase in ACh induced by dopamine receptor stimulation with apomorphine and was not prevented by dopamine receptor blockade with pimozide. On the other hand, apomorphine's effect was blocked by (-)-fenfluramine while pimozide pretreatment unmasked an increase in ACh induced by (-)-fenfluramine. The results favour the notion that there is a population of cholinergic neurons intrinsic to the striatum which is under inhibitory 5-HT regulation and independent of inhibitory dopamine regulation.

References

Oct 1, 1979·The Journal of Pharmacy and Pharmacology·S ConsoloA S Tirelli
Feb 7, 1977·European Journal of Pharmacology·C EuvrardJ Glowinski
May 1, 1974·European Journal of Pharmacology·A JoriR Samanin

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Citations

May 19, 1989·European Journal of Pharmacology·R InvernizziR Samanin
Apr 1, 1984·Pharmacology, Biochemistry, and Behavior·K L PrestonC R Schuster
Jan 1, 1987·Pharmacology & Therapeutics·M F Sugrue
May 1, 1990·The British Journal of Nutrition·M HorowitzD Shearman
May 1, 1989·British Journal of Pharmacology·C BianchiL Beani
Jan 1, 1982·The Journal of Pharmacy and Pharmacology·J A HirschR J Wurtman

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