Comparison of the effects of the three major tyrosine kinase inhibitors as first-line therapy for non-small-cell lung cancer harboring epidermal growth factor receptor mutations

Oncotarget
Chih-Yen TuChia-Hung Chen

Abstract

Patients with advanced lung adenocarcinoma harboring epidermal growth factor receptor (EGFR)-activating mutations have good response rate and longer progression-free survival (PFS) when treated with the tyrosine kinase inhibitors (TKI) compared with platinum-based chemotherapy. However, studies comparing the effectiveness of these drugs as first-line therapy in such patients are limited. We analyzed 422 patients with EGFR-mutated advanced lung adenocarcinoma receiving first-line gefitinib (n = 195, 46.2%), erlotinib (n = 123, 29.1%), or afatinib (n = 104, 24.6%). The PFS of the afatinib group was longer (12.2 months) than that of the gefitinib group (9.8 months) (p = 0.035) but similar to that of the erlotinib group (11.4 months) (p = 0.38). In patients without brain metastasis (BM), subgroup analysis showed that the afatinib group had significantly longer PFS (13.1 months) than erlotinib (11.7 months) and gefitinib (9.8 months) groups (p = 0.010). Patients with exon 19 deletions in the afatinib and erlotinib groups had potentially long PFS (p = 0.073). Efficacy of afatinib was similar between the 30 mg and 40 mg arms (median PFS 16.1 months vs. 10.3 months; p = 0.923). Afatinib may be the optimal EGFR-TKI for advanced lung ade...Continue Reading

References

Jul 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David M JackmanPasi A Jänne
Aug 21, 2009·The New England Journal of Medicine·Tony S MokMasahiro Fukuoka
Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Jul 3, 2010·The European Respiratory Journal·R PortaR Rosell
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra P D'AngeloMark G Kris
Jan 31, 2012·The Lancet Oncology·Rafael RosellUNKNOWN Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia T
Aug 14, 2012·The Journal of Pharmacology and Experimental Therapeutics·Flavio SolcaGuenther R Adolf
Sep 13, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A InoueUNKNOWN North-East Japan Study Group
Jul 3, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lecia V SequistMartin Schuler
Sep 12, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·T IuchiT Iizasa
Jan 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yuankai ShiPan-Chyr Yang
Jan 31, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H A YuG J Riely
Feb 11, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Chao-Hua ChiuJames Chih-Hsin Yang
May 16, 2015·Cancer Metastasis Reviews·Stefan Zimmermann, Solange Peters
Jan 30, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Martin SchulerJames C-H Yang
Mar 30, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yoshiko UrataYoichi Nakanishi
Dec 27, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Emily CastellanosLeora Horn
Apr 21, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L Paz-AresK Park

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Citations

Apr 26, 2019·Therapeutic Advances in Medical Oncology·Keunchil ParkJames Chih-Hsin Yang

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