Abstract
Cancer treatment with several kinds of drugs, especially targets the apoptotic pathways nowadays. TNF-related apoptosis-inducing ligand (TRAIL) as one of the important members of death receptors, significantly trigger induction of apoptosis in cancer cells. Three conserved domains of Death receptor (DR5) protein extracellular domain, which are fortified cysteine, were chosen and chemically synthesised. Hens were immunised with nano-liposomal peptides, and as a result the purified Immunoglobulin (IgYs) remarkably killed the cancerous MCF7 cells. The flow cytometric assay, confirmed the apoptotic death. Among several kinds of carriers that were used in this research, the nano-liposomal and nanoparticle conjugated, both were acceptable choices for drug delivery. Furthermore, the IgY against DR5's small peptides with such carriers successfully reached the target and significantly killed the cancer cells via apoptosis.
References
Jun 24, 1991·Journal of Immunological Methods·C R Alving
Dec 1, 1969·The Journal of Experimental Medicine·G A Leslie, L W Clem
Apr 4, 1997·Science·G PanV M Dixit
Aug 8, 1997·Science·J P SheridanA Ashkenazi
Oct 6, 1997·The EMBO Journal·H WalczakC T Rauch
Dec 31, 1997·FEBS Letters·P SchneiderJ Tschopp
Jan 26, 1999·Advances in Immunology·P H Krammer
Feb 4, 1999·Nature Medicine·H WalczakD H Lynch
Mar 13, 1999·International Journal of Cancer. Journal International Du Cancer·G J LemamyJ P Brouillet
Apr 21, 1999·Current Opinion in Cell Biology·A Ashkenazi, V M Dixit
May 10, 2000·Nature Medicine·M JoS C Strom
Apr 3, 2001·Nature Medicine·D LawrenceA Ashkenazi
Jan 5, 2002·Advances in Experimental Medicine and Biology·A R Collins
Jun 22, 2002·Research in Veterinary Science·J A AmaralS B Carbonare
Nov 5, 2002·Clinical and Diagnostic Laboratory Immunology·Arlene R Collins
Jun 15, 2005·ILAR Journal·Jann Hau, Coenraad F M Hendriksen
Oct 20, 2005·The Journal of Biological Chemistry·Yabin GuoYanxin Liu
Nov 6, 2007·Current Drug Delivery·Abdus SamadM Aqil
Dec 20, 2007·Molecular Cancer Therapeutics·Leo Christopher DerosierDonald J Buchsbaum
Mar 6, 2008·Cellular & Molecular Immunology·Jing WangYan Li
Jan 20, 2009·Reviews on Recent Clinical Trials·Anita C BellailChunhai Hao
Mar 4, 2011·Cell Death & Disease·C R ReisW J Quax
May 5, 2011·Cancer Biotherapy & Radiopharmaceuticals·Yao-Wu DuYuan-Fang Ma
Dec 6, 2011·Annual Review of Food Science and Technology·Jennifer Kovacs-Nolan, Yoshinori Mine
Jan 11, 2012·Biochemical Pharmacology·Kuen-Feng ChenAnn-Lii Cheng
Apr 14, 2012·Current Drug Metabolism·Mohammad-Ali Shahbazi, Hélder A Santos
Feb 26, 2013·Nanoscale Research Letters·Abolfazl AkbarzadehKazem Nejati-Koshki
Jun 19, 2013·Cancer Chemotherapy and Pharmacology·Hong XiangLisa A Damico-Beyer