Comparison of the effects of treatment of peri-implant infection in animal and human studies: systematic review and meta-analysis

Clinical Oral Implants Research
Clovis Mariano FaggionYu-Kang Tu

Abstract

The main objective of this systematic review is to compare the effects of treatment of peri-implant infection between animal and human studies. A literature search was conducted using the Medline, Cochrane Central Register of Controlled Trials, and Latin American and Caribbean Health Sciences Literature databases up to and including May 2008. In addition, bibliographies of systematic reviews on peri-implant diseases were searched manually. Non-surgical and surgical treatments of peri-implantitis/mucositis in animal models or human studies were compared. Meta-analysis was conducted to investigate the difference between the reported treatment effects in animal and human studies. Changes in probing pocket depth (PPD) and probing attachment level (PAL) from baseline measurements were used as measures of outcome. Single-level and multilevel meta-regression analysis was performed by taking into account the different follow-up times of the studies included. The single-level and multilevel random-effects meta-analysis showed that the difference in PPD reduction [0.31 mm, 95% confidence interval (CI): -0.27, 0.88] and in PAL gain (0.21 mm, 95% CI: -0.47, 0.88) between animal and human studies was not statistically significant. The rando...Continue Reading

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May 29, 2010·Journal of Periodontology·Leandro ChambroneLuiz A Lima
Jan 14, 2012·British Dental Journal·N MattheosA D Walmsley
Sep 20, 2011·The Veterinary Journal·C M FaggionN N Giannakopoulos
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Aug 13, 2011·Clinical Implant Dentistry and Related Research·Clovis Mariano FaggionYu-Kang Tu
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