PMID: 6413957Mar 1, 1983Paper

Comparison of the effects of TRH and D-Ala2-metenkephalinamide on hippocampal electrical activity and behavior in the unanesthetized rat

Peptides
E G Drust, I L Crawford

Abstract

Administration of TRH into the lateral ventricle of unanesthetized rats produced increases in the incidence of hippocampal theta (5.9-9.1 Hz) rhythm, locomotor activity and shaking behavior. The increase in theta rhythm produced by TRH was brief (less than 5 min) and was coincident with a brief, large increase in locomotor activity. Intracerebroventricular injection of either TRH or D-Ala2-metenkephalinamide (D-Ala2-ME) also induced episodes of shaking behavior. Shakes induced by D-Ala2-ME were associated with the occurrence of hippocampal epileptiform activity whereas those caused by TRH occurred in the absence of any recorded abnormalities in hippocampal activity. These results suggest that the increase in hippocampal theta rhythm after TRH is secondary to the increase in locomotor activity and, that in contrast to enkephalins, shaking behavior caused by TRH may not be related to an action on the electrographic activity of the hippocampus.

References

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Jun 13, 1975·Science·H TeitelbaumJ N Johannessen
Jan 1, 1978·Pharmacology, Biochemistry, and Behavior·I Urban, D De Wied
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S J HenriksenR Guillemin
Apr 1, 1969·Electroencephalography and Clinical Neurophysiology·C H Vanderwolf
Jul 1, 1971·Journal of Comparative and Physiological Psychology·C A SandmanA J Kastin
Jan 21, 1982·The New England Journal of Medicine·I M Jackson

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