PMID: 9449265Feb 4, 1998Paper

Comparison of the efficacies of three fluoroquinolone antimicrobial agents, given as continuous or pulsed-water medication, against Escherichia coli infection in chickens

Antimicrobial Agents and Chemotherapy
B CharlestonR Froyman

Abstract

This study compared the efficacy of continuous or pulsed-water medication with enrofloxacin, danofloxacin, and sarafloxacin in eight groups of 90 chicks each by using an infectious bronchitis virus-Escherichia coli model of colisepticemia. The model produced lesions of typical those occurring in birds with severe colisepticemia; for the infected, nonmedicated birds the mortality was 43.5% and the morbidity was 89%, 17.8% of birds had severe lesions, and the birds had a mean air sac lesion score of 2.58. This experiment showed that continuous dosing and pulsed dosing are clinically equivalent. However, for all fluoroquinolones studied, there was a trend for the continuously mediated birds to have lower mortality and less severe disease than birds receiving pulsed doses. Compared with infected, nonmedicated controls, only birds continuously medicated with enrofloxacin had a significantly lower morbidity (32%), and only birds medicated with enrofloxacin and danofloxacin (continuous and pulsed treatments) had significantly lower mortality (6.7 and 11.0% and 16.8 and 19.2% for continuous and pulsed treatments with enrofloxacin and danofloxacin, respectively). A significantly lower proportion of birds only in the groups medicated wit...Continue Reading

References

Oct 1, 1985·Antimicrobial Agents and Chemotherapy·J S Wolfson, D C Hooper
Mar 1, 1993·Antimicrobial Agents and Chemotherapy·G L DrusanoH C Standiford
Apr 1, 1978·Avian Pathology : Journal of the W.V.P.A·E Goren

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Citations

Sep 28, 2006·Veterinary Research Communications·A M HaritovaJ Fink-Gremmels
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Aneliya Milanova HaritovaJohanna Fink-Gremmels
Dec 17, 2002·The Journal of General and Applied Microbiology·Moustafa Y. M. El-NaggarMona Z. Sahaly
Feb 9, 2021·Research in Veterinary Science·Irene SartiniMario Giorgi

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