Comparison of the efficacy and mechanisms of intranasal budesonide, montelukast, and their combination in treatment of patients with seasonal allergic rhinitis

International Forum of Allergy & Rhinology
Hui ChenChengshuo Wang

Abstract

Although intranasal steroids and anti-cysteinyl-leukotriene-receptor antagonists are efficacious in the treatment of seasonal allergic rhinitis (SAR), combinations of these agents have not unequivocally been demonstrated to be superior to the individual drugs. We aimed to compare the efficacy and potential mechanisms of budesonide nasal spray (BD), oral montelukast (MNT), and combination therapy comprising a half-dose of budesonide plus montelukast (hBD+MNT) in SAR patients. We performed a single-center, randomized, open-label study in SAR subjects (n = 100). Participants were randomized to receive BD (256 μg), MNT (10 mg), or hBD (128 μg)+MNT for 14 days. Symptom severity scores, nasal cavity volume (NCV), fraction of exhaled nitric oxide (FeNO), eosinophil cationic protein (ECP), histamine and cysteinyl-leukotrienes (CysLTs), and T-cell subsets were assessed before and after treatment. All treatments significantly improved symptoms from baseline; however, hBD+MNT produced significantly greater improvements in nasal congestion compared with BD or MNT alone. The BD and hBD+MNT groups had fewer patients with uncontrolled symptoms and improved NCV to a greater level than the MNT group. FeNO was decreased to a significantly greate...Continue Reading

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Citations

Oct 30, 2018·International Forum of Allergy & Rhinology·Luo Zhang
Sep 12, 2020·Drugs·Madhusudhan KrishnamoorthyBaharudin Abdullah
Jan 26, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Angelica TiotiuFulvio Braido
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou
May 26, 2021·Expert Review of Respiratory Medicine·Angelica TiotiuFulvio Braido

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