PMID: 1360803Nov 1, 1992

Comparison of the efficacy of esmolol and alfentanil to attenuate the hemodynamic responses to emergence and extubation

Journal of Clinical Anesthesia
T M FuhrmanJ M Weaver


To define the ability of esmolol and alfentanil to control the hemodynamic changes associated with extubation and emergence. Randomized, double-blind, placebo-controlled study. General surgery operating rooms at a university hospital. Forty-two ASA physical status I and II patients without history of cardiac or pulmonary disease undergoing surgery not involving the cranium or thorax. Patients were given either a bolus dose of normal saline followed by an infusion of normal saline, a bolus dose of alfentanil 5 micrograms/kg followed by an infusion of normal saline, or a bolus dose of esmolol 500 micrograms/kg followed by an infusion of esmolol 300 micrograms/kg/min. Emergency and extubation resulted in significant increases in heart rate (HR) and blood pressure (BP) in the placebo group. Alfentanil controlled the responses to emergence but prolonged the time to extubation (p < 0.05). Esmolol significantly controlled the responses to emergence and extubation (p < 0.05). Emergence and extubation after inhalation general anesthesia result in significant increases in BP and HR in healthy patients. An esmolol bolus dose and subsequent infusion significantly attenuated these responses. A small bolus dose of alfentanil minimized the re...Continue Reading


Jun 16, 1978·JAMA : the Journal of the American Medical Association·P A SteenS Tarhan
Jan 1, 1991·Anesthesiology·S L Shafer, J R Varvel
Jan 1, 1990·Anesthesia and Analgesia·D A MuzziR F Cucchiara
Mar 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S SheppardL Strunin
Dec 1, 1990·Anesthesia and Analgesia·A DysonJ M Lipton
Feb 1, 1989·Anesthesia and Analgesia·M I GoldC A Skillman
Oct 1, 1988·Anesthesiology·M E MahlaM D Moneta
Aug 1, 1982·British Journal of Anaesthesia·S Bower, C J Hull


Oct 16, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y FujiiH Toyooka
Jul 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K NishinaH Obara
Feb 24, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·E M DavidsonJ E Chelly
Mar 3, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Hang ZhaoSatoshi Kashimoto
Mar 1, 1995·Journal of Clinical Anesthesia·P MendelP F White
Jan 1, 1995·Acta Anaesthesiologica Scandinavica·K NishinaH Obara
May 30, 1998·Acta Anaesthesiologica Scandinavica·A M KoivusaloL Lindgren
Feb 10, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Anthony L Kovac, Amy Masiongale
Oct 6, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Giovanni LandoniAlberto Zangrillo
Jun 19, 2003·Anesthesiology Clinics of North America·Tracey Stierer, Lee A Fleisher
Jan 24, 2007·European Journal of Anaesthesiology·M DurmusM O Ersoy
Aug 13, 2005·Acta Anaesthesiologica Scandinavica·G GulerA Boyaci
Jun 1, 1995·Anesthesia and Analgesia·K NishinaH Obara
Jan 1, 1995·Anesthesia and Analgesia·K A MillerP L Bailey
Oct 2, 2013·Iranian Red Crescent Medical Journal·Mohammad Taghy Moein VaziriAshkan Panah
Aug 26, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y FujiiH Toyooka

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Esmolol hydrochloride
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