Comparison of the Efficiency of Systemic and Local Cell Therapy with Human Umbilical Cord Blood Mononuclear Cells in Rats with Severe Spinal Cord Injury.

Bulletin of Experimental Biology and Medicine
S I RyabovV A Smirnov

Abstract

Rat model of severe contusion spinal cord injury was used to study the effect of single intravenous and intraspinal injection of human umbilical cord blood mononuclear cells on the restoration of motor function of the hind limbs. Recovery of the motor function of the hind limbs was assessed using load tests and open-field test according to BBB scale. Cell injection via both routes significantly improved (p≤0.05) the recovery of the motor function of the hind limbs by 35-40% relative to the level of "self-recovery"; the effects of intravenous andintraspinal administration did not differ significantly.

References

Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Jun 6, 2009·Bulletin of Experimental Biology and Medicine·S V LebedevV P Chekhonin
Jun 10, 2014·Bulletin of Experimental Biology and Medicine·S I RyabovV P Chekhonin
Mar 30, 2017·Neurosurgery·Christopher S AhujaMichael G Fehlings
Apr 26, 2017·Nature Neuroscience·Peggy AssinckWolfram Tetzlaff
Jun 13, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mina RizkDavid S Allan
Apr 12, 2018·Cell Transplantation·Hongyun HuangTong Li
Jan 6, 2019·Journal of Neurosurgery. Spine·Jetan H BadhiwalaMichael G Fehlings

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.