Comparison of the elimination between perfluorinated fatty acids with different carbon chain length in rats

Chemico-biological Interactions
N KudoY Kawashima

Abstract

Elimination in urine and feces was compared between four perfluorinated fatty acids (PFCAs) with different carbon chain length. In male rats, perfluoroheptanoic acid (PFHA) was rapidly eliminated in urine with the proportion of 92% of the dose being eliminated within 120 h after an intraperitoneal injection. Perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA) was eliminated in urine with the proportions of 55, 2.0 and 0.2% of the dose, respectively. By contrast, four PFCAs were eliminated in feces with the proportion of less than 5% of the dose within 120 h after an injection. In female rats, the proportions of PFOA and PFNA eliminated in urine within 120 h were 80% and 51% of the dose, respectively, which were significantly higher compared with those in male rats. There was the tendency that PFCA with longer carbon chain length is less eliminated in urine in both male and female rats. Fecal elimination of PFCAs was not different between PFCAs in female rats and comparable to those in male rats. The rates of biliary excretion of PFCAs in male rats were slower than those in female rats. Sex-related difference in urinary elimination of PFOA was abolished when male rats had been castrated...Continue Reading

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Citations

May 27, 2009·Archives of Environmental Contamination and Toxicology·Lin CuiGui-bin Jiang
May 7, 2013·Environmental Science and Pollution Research International·Robin VestergrenIan T Cousins
Nov 13, 2013·Aquatic Toxicology·Mazhar UlhaqLeif Norrgren
May 22, 2013·Chemosphere·Guang-Wen LienPau-Chung Chen
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Sep 6, 2011·Reproductive Toxicology·Shu-Ching ChangJohn L Butenhoff
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Nov 26, 2014·Journal of Occupational Health·Yukiko FujiiAkio Koizumi
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