Comparison of the epinephrine-induced arrhythmogenic effect of sevoflurane with isoflurane and halothane

Journal of Anesthesia
S Imamura, K Ikeda

Abstract

The effect of sevoflurane on cardiac arrhythmias induced by the infusion of epinephrine into dogs was compared with those of isoflurane and halothane. The arrhythmogenic doses of epinephrine determined in this comparative study were expressed by both infusion rates of epinephrine and the corresponding plasma levels obtained by a series of three-minute epinephrine infusions during sevolurane, isoflurane, and halothane anesthesia at 1.25 MAC. The mean values of the arrythmogenic infusion rates of epinephrine and the corresponding plasma levels were 17.3 microg/kg/min and 275.7 ng/ml for sevoflurane, 6.7 microg/kg/min and 149.2 ng/ml for isoflurane and 1.9 microg/kg/min and 39.1 ng/ml for halothane, respectively. These results indicate that the arrythmogenic doses of epinephrine during sevoflurane and isoflurane anesthesia were significantly higher than those during halothane anesthesia.

References

Jul 1, 1975·Anesthesia and Analgesia·L S Reisner, M Lippmann
Nov 1, 1975·Anesthesia and Analgesia·R F WallinI J Stern
Sep 1, 1973·Anesthesia and Analgesia·E B Thompson, F T Galysh

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Citations

Feb 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M Doi, K Ikeda
Dec 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T Katoh, K Ikeda
Nov 1, 1995·Journal of Clinical Anesthesia·C J Young, J L Apfelbaum
Oct 18, 2006·Journal of the American Veterinary Medical Association·Kristen G Hunyady, Rebecca A Johnson
Mar 19, 2013·The Veterinary Clinics of North America. Equine Practice·Stijn Schauvliege, Frank Gasthuys
Dec 1, 1994·Journal of Anesthesia·Matsuyuki Doi, Kazuyuki Ikeda
Jul 3, 1998·European Journal of Anaesthesiology·A Michalek-SaubererM Semsroth

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