Comparison of the expression of human leukocyte antigen (HLA)-G and HLA-E in women with normal pregnancy and those with recurrent miscarriage

Reproduction : the Official Journal of the Society for the Study of Fertility
A BhallaL W Chamley

Abstract

Recurrent miscarriage affects 1% of all couples attempting pregnancy. Immunological factors are postulated to play a role in the aetiology of recurrent miscarriage because the fetus and placenta are immunologically different from the mother. In particular, altered expression of the, non-classical, class I histocompatibility leukocyte antigen (HLA) molecules has been postulated to play a role in the aetiology of recurrent miscarriage as the fetus and placenta are semi-allogenic to the mother. This study was conducted to examine whether altered expression of the non-classical class I HLA molecules, HLA-G and HLA-E, by cells at the maternofetal interface could play a role in the aetiology of recurrent miscarriage. First-trimester placental and decidual biopsies were obtained from 45 women with recurrent miscarriage and 17 gestation-matched normal controls. These biopsies were screened by immunohistochemistry for HLA-G and HLA-E and isotype-matched control antibodies. Staining was analysed by light microscopy and digital image analysis. In both recurrent miscarriage and normal pregnancy, HLA-G was localised to the extravillous trophoblast. There was no difference in the pattern of HLA-G expression between women with recurrent misca...Continue Reading

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Citations

Nov 25, 2011·Human Reproduction Update·Mette Dahl, Thomas Vauvert F Hviid
Nov 18, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Juan Pedro KusanovicSonia S Hassan
Nov 26, 2010·Medical Hypotheses·Wei ChenSen-Lin Zhang
Feb 2, 2010·Reproductive Biomedicine Online·Valerie ShaiklyNelson Fernández
Feb 26, 2009·American Journal of Reproductive Immunology : AJRI·Zhongying HuangYuji Taketani
Mar 18, 2011·Scandinavian Journal of Immunology·Y M MosaadS M El-Sherbini
Mar 1, 2012·American Journal of Reproductive Immunology : AJRI·Atsushi FukuiHideki Mizunuma
Jun 24, 2015·Scandinavian Journal of Immunology·Y M Mosaad
Feb 24, 2015·Human Immunology·Tess MeulemanKitty W M Bloemenkamp
Jan 8, 2015·Frontiers in Immunology·Snezana Djurisic, Thomas Vauvert F Hviid
Oct 24, 2014·Frontiers in Immunology·Erick C CastelliCelso T Mendes-Junior
Jun 28, 2017·American Journal of Reproductive Immunology : AJRI·Chunyu HuangWenwei Tu
Jan 15, 2020·Nature Reviews. Rheumatology·Frauke Förger, Peter M Villiger
Jun 13, 2020·International Reviews of Immunology·Xiaopeng LiBolan Yu
Apr 24, 2019·Advanced Pharmaceutical Bulletin·Elnaz MosaferiBehzad Baradaran
Sep 30, 2020·Journal of Reproductive Immunology·Beatriz GuerreroRaquel Tarazona

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