Abstract
Left atrial appendage closure (LAAC) is considered an alternative to oral anticoagulation therapy in patients with atrial fibrillation (AF). The aim of this study was to compare the safety and efficacy of the first- and second-generation AMPLATZER Devices for LAAC, AMPLATZER Cardiac Plug (ACP) versus AMPLATZER Amulet™. Procedural data, such as fluoroscopy time, radiation dose, and contrast-dye, as well as VARC criteria and major adverse events (MAEs) were assessed for both devices. The rate of peridevice leaks was analyzed at echocardiographic follow-up. A total of 196 patients with AF underwent LAAC with the ACP (n = 99) or Amulet device (n = 97). The use of Amulet was associated with significantly lower fluoroscopy time (14.8 ± 7.4 min versus 10.6 ± 4.1 min; p < 0.001), lower radiation dose (4833 ± 3360 cGy⁎cm2 versus 3206 ± 2169 cGy⁎cm2; p < 0.001), and reduced amount of contrast-dye (150.2 ± 83.9 ml versus 128.8 ± 46.0 ml; p = 0.03). Furthermore, LAAC with Amulet devices resulted in lower device-resizing rates (3 versus 16 cases; p = 0.001). Peridevice leaks were less frequent in the Amulet group (12 versus 4; p = 0.03). MAE occurred in 6 ACP and 4 Amulet patients (p = 0.58). The Amulet device is associated with shorter flu...Continue Reading
References
Sep 3, 2003·Journal of Cardiovascular Electrophysiology·Heyder OmranBerndt Lüderitz
Aug 18, 2009·Lancet·David R HolmesUNKNOWN PROTECT AF Investigators
Sep 9, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jai-Wun ParkBoris Leithäuser
Oct 6, 2012·Journal of the American College of Cardiology·A Pieter KappeteinMartin B Leon
Jan 1, 2013·International Journal of Cardiology·Xavier FreixaRéda Ibrahim
Jan 24, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Xavier FreixaRéda Ibrahim
May 14, 2014·International Journal of Cardiology·Xavier FreixaRéda Ibrahim
Jul 7, 2014·Journal of the American College of Cardiology·David R HolmesVivek Y Reddy
Aug 31, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Bernhard MeierUNKNOWN Document Reviewers
Jan 22, 2015·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Apostolos TzikasJai-Wun Park
Mar 5, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Steffen GloeklerBernhard Meier
May 14, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Apostolos TzikasThorsten Lewalter