Comparison of the first- and second-generation limus-eluting stents for bifurcation lesions from a Korean multicenter registry

Circulation Journal : Official Journal of the Japanese Circulation Society
Youngjin ChoHyo-Soo Kim

Abstract

There are limited data on the relative efficacy of 1st- vs. 2nd-generation limus-eluting stents in bifurcation lesions. METHODS AND RESULTS: Our analysis of a Korean multicenter registry for bifurcated coronary lesions enrolled 1,762 patients treated with 2nd-generation everolimus-eluting stent (EES, n=348) or 1st-generation sirolimus-eluting stents (SES, n=1,414). In the overall population, EES was comparable to SES regarding major adverse cardiac events (MACE: composite of cardiac death, nonfatal myocardial infarction, and target vessel revascularization (TVR)), cardiac death, and TVR rates within a 2-year follow-up. In 1:3 propensity score-matched populations, EES showed a significantly lower MACE rate compared with SES (HR [95% CI], 0.53 [0.29-0.97]; P=0.039), mainly through a reduction in repeat revascularization (HR [95% CI], 0.47 [0.24-0.92]; P=0.027). EES was superior to SES in reducing TVR in patients with left main (LM) lesions (HR [95% CI], 0.21 [0.06-0.67]; P=0.008) or in patients treated with 2-stent technique PCI (HR [95% CI], 0.28 [0.09-0.91]; P=0.035). There was no difference in clinical outcomes between 2 stents in a non-LM bifurcation lesion or in patients treated with a 1-stent technique. At 2-year follow-up,...Continue Reading

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Mar 17, 2006·Revista española de cardiología·Alfonso MedinaManuel Pan
May 7, 2010·The New England Journal of Medicine·Gregg W StoneUNKNOWN SPIRIT IV Investigators
Apr 17, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Jin-Wook ChungHyo-Soo Kim
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Jun 28, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Shunsuke KuboKazuaki Mitsudo

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Citations

Nov 20, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Jeong Hoon YangSeung-Hyuk Choi
Jul 3, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Taek Kyu ParkHyeon-Cheol Gwon
Mar 27, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Seung Hwa LeeHyeon-Cheol Gwon

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