Comparison of the first episode with the first recurrent episode of takotsubo syndrome in 128 patients from the world literature: Pathophysiologic connotations

International Journal of Cardiology
John E Madias

Abstract

The pathophysiology of takotsubo syndrome (TTS) and its recurrence (REC-TTS) is still elusive. Various ventriculographic "ballooning" patterns in response to a variety of triggers are observed in patients with REC-TTS. Although patients with and without REC-TTS have been previously compared, no comparison of patients' 1st TTS episode (1stTTS) with the 1st REC-TTS episode (1stREC-TTS) has been attempted. All patients with ≥1 REC-TTS episodes with patient-based data (45 variables) from the world literature, retrieved via PubMed, were meta-analyzed, and the patients' 1st REC-TTS and stREC-TTS were compared. The time interval between the 1stTTS and 1stREC-TTS of the meta-analyzed 128 patients, 117 (91.4%) female, was 30.4 ± 36.1 months, with 47 (36.7%) patients having a neurological and/or psychiatric comorbidity(ies). Among 113 patients with paired 1stTTS and 1stREC-TTS data on the ventriculographic "ballooning" appearance, 101 (78.9%) had a different variant during the 1stTTS as compared with the 1stREC-TTS. Six patients (4.7%) died during hospitalization. Thirty patients (23.4%) were taking a β-blocker prior to their 1strTTS. Among 19 variables compared between the 1st TTS and 1st REC-TTS episodes, only mean age (by 2.5 years) a...Continue Reading

Citations

Jun 21, 2020·Echocardiography·Nicola TarantinoNatale Daniele Brunetti
Jan 10, 2021·Heart·Christopher LauMing-Sum Lee
Jan 23, 2021·Heart & Lung : the Journal of Critical Care·Keerat Rai AhujaJohn E Madias
Feb 8, 2021·International Journal of Cardiology·John E Madias
Mar 1, 2021·International Journal of Cardiology·Luca ArcariMaria Beatrice Musumeci
Aug 8, 2021·Journal of Clinical Medicine·John E Madias

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