Comparison of the fixative properties of five disinfectant solutions

The Journal of Hospital Infection
L PineauD Luu Duc

Abstract

Following a French circular published in 2001, the use of glutaraldehyde for the disinfection of reusable medical devices was abandoned in favour of non-fixative disinfectants such as peracetic-acid-based solutions. Data published regarding the fixative properties of alternative disinfectants remain contradictory. We compared the effect of repetitive treatments of polytetrafluoroethylene (PTFE) tubes, contaminated by a liquid medium inoculated with Pseudomonas aeruginosa, using five different disinfectant solutions: two peracetic acid solutions (with and without an activator), glutaraldehyde, ortho-phthaldehyde and succine dialdehyde. The results confirmed that repeated treatments of a PTFE tube with a 2% glutaraldehyde solution induce an important accumulation and/or fixation of protein, compared to peracetic-acid-based disinfectants, for which the accumulation and/or fixation of proteins remain low and vary from one formulation to another.

References

Mar 1, 1991·Veterinary Microbiology·D M Taylor
Dec 8, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·K AntlogaG E McDonnell
Jun 9, 2004·The Journal of Hospital Infection·G KampfH Martiny
Aug 11, 2004·Lancet·Guillaume FichetJean-Philippe Deslys

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Citations

Aug 4, 2009·The Journal of Hospital Infection·M EterpiV Thomas
Sep 18, 2014·World Journal of Gastrointestinal Endoscopy·Günter KampfHeike Martiny

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